Sandbox Reserved 1482: Difference between revisions
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Factor VIIIa is obtained by cleavage and release of the B domain <ref name="wikipedia" /><ref name="Ngo" /><ref name="toole">Toole, J. J., Pittman, D. D., Orr, E. C., Murtha, P., Wasley, L. C., & Kaufman, R. J. (1986). A large region (approximately equal to 95 kDa) of human factor VIII is dispensable for in vitro procoagulant activity. Proceedings of the National Academy of Sciences, 83(16), 5939-5942.</ref>. Although factor VIIIa can be formed from at least two cleavages involving Arg372 and Arg1689, fully factor VIIIa is obtained by a third cleavage at Arg740 <ref name="Ngo" />. | Factor VIIIa is obtained by cleavage and release of the B domain <ref name="wikipedia" /><ref name="Ngo" /><ref name="toole">Toole, J. J., Pittman, D. D., Orr, E. C., Murtha, P., Wasley, L. C., & Kaufman, R. J. (1986). A large region (approximately equal to 95 kDa) of human factor VIII is dispensable for ''in vitro'' procoagulant activity. Proceedings of the National Academy of Sciences, 83(16), 5939-5942.</ref>. Although factor VIIIa can be formed from at least two cleavages involving Arg372 and Arg1689, fully factor VIIIa is obtained by a third cleavage at Arg740 <ref name="Ngo" />. | ||
The two chain that result are a heavy and a light chains <ref name="Ngo" /><ref name="El" /><ref name="pdb" />. | The two chain that result are a heavy and a light chains <ref name="Ngo" /><ref name="El" /><ref name="pdb" />. | ||
