Sandbox Reserved 1493: Difference between revisions
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=== KQAGDV binding site === | === KQAGDV binding site === | ||
On stimulated platelets, αIIbβ3 has a highly specific receptor for the plasma protein '''fibrinogen'''. The '''KQAGDV binding site''' interacts with the fibrinogen γ-chain C terminus at the <scene name='80/802667/Fibrinogen_gamma_c_from_2vdo/4'>γHHLGGAKQAGDV sequence</scene> (residues 400 to 411 of γC). <scene name='80/802667/Fibrinogen_gamma_c_kqagd/3'>KQAGD</scene> is the minimal binding motif for αIIbβ3. The <scene name='80/802667/2vdo_asp_mg/3'>Asp side chain interacts with Mg2+</scene> (MIDAS) and the Gly residue enters in a pocket between the two subunits. The peptide of the ligand extends on a large active site on the integrin and has a turn in the backbone that leads the Lys side chain of the | On stimulated platelets, αIIbβ3 has a highly specific receptor for the plasma protein '''fibrinogen'''. The '''KQAGDV binding site''' interacts with the fibrinogen γ-chain C terminus at the <scene name='80/802667/Fibrinogen_gamma_c_from_2vdo/4'>γHHLGGAKQAGDV sequence</scene> (residues 400 to 411 of γC). <scene name='80/802667/Fibrinogen_gamma_c_kqagd/3'>KQAGD</scene> is the minimal binding motif for αIIbβ3. The <scene name='80/802667/2vdo_asp_mg/3'>Asp side chain interacts with Mg2+</scene> (MIDAS) and the Gly residue enters in a pocket between the two subunits. The peptide of the ligand extends on a large active site on the integrin and has a turn in the backbone that leads the Lys side chain of the KQAGDV sequence into a pocket, so that its ammonium group is involved in hydrogen bonding with the αIIb subunit. | ||
=== RGD binding site === | === RGD binding site === | ||
