Mu Opioid Receptor: Difference between revisions

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== Mu Opioid Receptor==

Opioid receptors are G-protein coupled receptors (GPCR), which bind endogenous opioid peptide neurotransmitters (such as enkephalins and endorphins) and exogenous synthetic opiate drugs (such as morphine, codeine, and heroin) as ligands to hinder pain-signaling in the brain, peripheral nerves, and digestive tract. μ-opioid receptors are one of the four major classes of opioid receptors, which also includes δ-opioid receptors, κ-opioid receptors, and nociceptin opioid receptors. The μ-opioid receptor MOR-1 is expressed by the gene OPRM1 in vertebrates. <ref>DOI: 10.1124/pr.112.007138</ref> MOR-1 has important implications as a target for pain relievers as well as a treatment for drug abuse.

Opioid receptors are G-protein coupled receptors (GPCR), which bind endogenous opioid peptide neurotransmitters (such as enkephalins and endorphins) and exogenous synthetic opiate drugs (such as morphine, codeine, and heroin) as ligands to hinder pain-signaling in the brain, peripheral nerves, and digestive tract. μ-opioid receptors are one of the four major classes of opioid receptors, which also includes δ-opioid receptors, κ-opioid receptors, and nociceptin opioid receptors. The '''μ-opioid receptor''' MOR-1 is expressed by the gene OPRM1 in vertebrates. <ref>DOI: 10.1124/pr.112.007138</ref> MOR-1 has important implications as a target for pain relievers as well as a treatment for drug abuse.

== Structural highlights ==

Mu Opioid Receptor: Difference between revisions

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 == Mu Opioid Receptor==
 <StructureSection load='4n6h' size='340' side='right' caption='Chimera of E. coli cytochrome B562 and human Delta Opioid 7TM Receptor complex with oleate, tartarate, naltrindole, oleate derivative and Na+ ion (PDB code [[4n6h]])' scene=''>
-Opioid receptors are G-protein coupled receptors (GPCR), which bind endogenous opioid peptide neurotransmitters (such as enkephalins and endorphins) and exogenous synthetic opiate drugs (such as morphine, codeine, and heroin) as ligands to hinder pain-signaling in the brain, peripheral nerves, and digestive tract.  μ-opioid receptors are one of the four major classes of opioid receptors, which also includes δ-opioid receptors, κ-opioid receptors, and nociceptin opioid receptors.  The μ-opioid receptor MOR-1 is expressed by the gene OPRM1 in vertebrates. <ref>DOI: 10.1124/pr.112.007138</ref> MOR-1 has important implications as a target for pain relievers as well as a treatment for drug abuse.
+Opioid receptors are G-protein coupled receptors (GPCR), which bind endogenous opioid peptide neurotransmitters (such as enkephalins and endorphins) and exogenous synthetic opiate drugs (such as morphine, codeine, and heroin) as ligands to hinder pain-signaling in the brain, peripheral nerves, and digestive tract.  μ-opioid receptors are one of the four major classes of opioid receptors, which also includes δ-opioid receptors, κ-opioid receptors, and nociceptin opioid receptors.  The '''μ-opioid receptor''' MOR-1 is expressed by the gene OPRM1 in vertebrates. <ref>DOI: 10.1124/pr.112.007138</ref> MOR-1 has important implications as a target for pain relievers as well as a treatment for drug abuse.
 == Structural highlights ==