6ir0: Difference between revisions
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==Zinc finger domain of the human DTX protein== | |||
<StructureSection load='6ir0' size='340' side='right'caption='[[6ir0]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6ir0]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IR0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6IR0 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RING-type_E3_ubiquitin_transferase RING-type E3 ubiquitin transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.27 2.3.2.27] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ir0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ir0 OCA], [http://pdbe.org/6ir0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ir0 RCSB], [http://www.ebi.ac.uk/pdbsum/6ir0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ir0 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/DTX2_HUMAN DTX2_HUMAN]] Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: RING-type E3 ubiquitin transferase]] | |||
[[Category: Miyamoto, K]] | [[Category: Miyamoto, K]] | ||
[[Category: Dtx]] | |||
[[Category: Ligase]] | |||
[[Category: Ring finger]] | |||
[[Category: Zinc finger]] | |||
Revision as of 10:57, 13 November 2019
Zinc finger domain of the human DTX protein
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