6nhw: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6nhw is ~~ON HOLD~~

==Structure of the transmembrane domain of the Death Receptor 5 - Dimer of Trimer==

~~Authors~~: ~~Chou~~, J.J., ~~Pan~~, L.~~, Fu, Q~~., ~~Zhao, L~~.~~, Chen, W~~.~~, Piai, A~~., ~~Fu, T~~.~~, Wu, H~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[6nhw]] is a 6 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NHW FirstGlance]. <br>

~~Description~~: ~~Structure~~ of ~~the transmembrane domain~~ of the ~~Death~~ Receptor 5 -~~Dimer~~ of ~~Trimer~~

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nhw OCA], [http://pdbe.org/6nhw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nhw RCSB], [http://www.ebi.ac.uk/pdbsum/6nhw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nhw ProSAT]</span></td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/TR10B_HUMAN TR10B_HUMAN]] Defects in TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:[http://omim.org/entry/275355 275355]]; also known as squamous cell carcinoma of the head and neck.

== Function ==

[[http://www.uniprot.org/uniprot/TR10B_HUMAN TR10B_HUMAN]] Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.<ref>PMID:15322075</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Chen, W]]

[[Category: Chou, J J]]

[[Category: Fu, Q]]

[[Category: Fu, T]]

[[Category: Pan, L]]

[[Category: Piai, A]]

[[Category: ~~Pan~~, ~~L]]~~

[[Category: Wu, H]]

~~[[Category: Chou, J.J~~]]

[[Category: Zhao, L]]

[[Category: ~~Chen, W~~]]

[[Category: Death receptor 5]]

[[Category: ~~Wu, H~~]]

[[Category: Immune system]]

[[Category: Preligand autoinhibition]]

[[Category: Transmembrane helix mediated signaling]]

[[Category: Transmembrane helix oligomer]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6nhw is ON HOLD
+==Structure of the transmembrane domain of the Death Receptor 5 - Dimer of Trimer==
+<StructureSection load='6nhw' size='340' side='right' caption='[[6nhw]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
-Authors: Chou, J.J., Pan, L., Fu, Q., Zhao, L., Chen, W., Piai, A., Fu, T., Wu, H.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6nhw]] is a 6 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NHW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NHW FirstGlance]. <br>
-Description: Structure of the transmembrane domain of the Death Receptor 5 -Dimer of Trimer
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nhw OCA], [http://pdbe.org/6nhw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nhw RCSB], [http://www.ebi.ac.uk/pdbsum/6nhw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nhw ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/TR10B_HUMAN TR10B_HUMAN]] Defects in TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:[http://omim.org/entry/275355 275355]]; also known as squamous cell carcinoma of the head and neck.
+== Function ==
+[[http://www.uniprot.org/uniprot/TR10B_HUMAN TR10B_HUMAN]] Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.<ref>PMID:15322075</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Chen, W]]
+[[Category: Chou, J J]]
 [[Category: Fu, Q]]
 [[Category: Fu, T]]
+[[Category: Pan, L]]
 [[Category: Piai, A]]
-[[Category: Pan, L]]
+[[Category: Wu, H]]
-[[Category: Chou, J.J]]
 [[Category: Zhao, L]]
-[[Category: Chen, W]]
+[[Category: Death receptor 5]]
-[[Category: Wu, H]]
+[[Category: Immune system]]
+[[Category: Preligand autoinhibition]]
+[[Category: Transmembrane helix mediated signaling]]
+[[Category: Transmembrane helix oligomer]]