8drh: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:8drh.jpg|left|200px]]
[[Image:8drh.jpg|left|200px]]


{{Structure
<!--
|PDB= 8drh |SIZE=350|CAPTION= <scene name='initialview01'>8drh</scene>
The line below this paragraph, containing "STRUCTURE_8drh", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)
|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY=  
or leave the SCENE parameter empty for the default display.
|GENE=  
-->
|DOMAIN=
{{STRUCTURE_8drh| PDB=8drh  | SCENE= }}  
|RELATEDENTRY=[[8psh|8PSH]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=8drh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8drh OCA], [http://www.ebi.ac.uk/pdbsum/8drh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=8drh RCSB]</span>
}}


'''HIGH RESOLUTION NMR STRUCTURE OF THE D(GCGTCAGG)R(CCUGACGC) HYBRID, MINIMIZED AVERAGE STRUCTURE'''
'''HIGH RESOLUTION NMR STRUCTURE OF THE D(GCGTCAGG)R(CCUGACGC) HYBRID, MINIMIZED AVERAGE STRUCTURE'''
Line 19: Line 16:


==About this Structure==
==About this Structure==
8DRH is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DRH OCA].  
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DRH OCA].  


==Reference==
==Reference==
Structure of a stereoregular phosphorothioate DNA/RNA duplex., Bachelin M, Hessler G, Kurz G, Hacia JG, Dervan PB, Kessler H, Nat Struct Biol. 1998 Apr;5(4):271-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9546216 9546216]
Structure of a stereoregular phosphorothioate DNA/RNA duplex., Bachelin M, Hessler G, Kurz G, Hacia JG, Dervan PB, Kessler H, Nat Struct Biol. 1998 Apr;5(4):271-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9546216 9546216]
[[Category: Protein complex]]
[[Category: Bachelin, M.]]
[[Category: Bachelin, M.]]
[[Category: Dervan, P B.]]
[[Category: Dervan, P B.]]
Line 30: Line 26:
[[Category: Kessler, H.]]
[[Category: Kessler, H.]]
[[Category: Kurz, G.]]
[[Category: Kurz, G.]]
[[Category: deoxyribonucleic acid/ribonucleic acid]]
[[Category: Deoxyribonucleic acid/ribonucleic acid]]
[[Category: dna/rna hybrid]]
[[Category: Dna/rna hybrid]]
[[Category: oligonucleotide]]
[[Category: Oligonucleotide]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 22:49:12 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:45:05 2008''

Revision as of 19:49, 4 May 2008

File:8drh.jpg

Template:STRUCTURE 8drh

HIGH RESOLUTION NMR STRUCTURE OF THE D(GCGTCAGG)R(CCUGACGC) HYBRID, MINIMIZED AVERAGE STRUCTURE


Overview

In this work, we present the first NMR solution structure of a DNA/RNA hybrid containing stereoregular Rp-phosphorothioate modifications of all DNA backbone linkages. The complex of the enzymatically synthesized phosphorothioate DNA octamer (all-Rp)-d(GCGTCAGG) and its complementary RNA r(CCUGACGC) was found to adopt an overall conformation within the A-form family. Most helical parameters and the sugar puckers of the DNA strand assume values intermediate between A- and B-form. The close structural similarity with the unmodified DNA/RNA hybrid of the same sequence may explain why both the natural and the sulfur-substituted complex can be recognized and digested by ribonuclease H.

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of a stereoregular phosphorothioate DNA/RNA duplex., Bachelin M, Hessler G, Kurz G, Hacia JG, Dervan PB, Kessler H, Nat Struct Biol. 1998 Apr;5(4):271-6. PMID:9546216 Page seeded by OCA on Sun May 4 22:49:12 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=8drh&oldid=534966"