6nom: Difference between revisions
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==NMR solution structure of Pisum sativum defensin 2 (Psd2) provides evidence for the presence of hydrophobic surface clusters== | |||
<StructureSection load='6nom' size='340' side='right'caption='[[6nom]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6nom]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NOM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NOM FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nom OCA], [http://pdbe.org/6nom PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nom RCSB], [http://www.ebi.ac.uk/pdbsum/6nom PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nom ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/DEF2_PEA DEF2_PEA]] Possesses antifungal activity sensitive to inorganic cations. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Pisum sativum defensin 2 (Psd2) is a small (4.7 kDa) antifungal peptide whose structure is held together by four conserved disulfide bridges. Psd2 shares the cysteine-stabilized alpha-beta (CSalphabeta) fold, which lacks a regular hydrophobic core. All hydrophobic residues are exposed to the surface, except for leucine 6. They are clustered in the surface formed by two loops, between beta1 and alpha-helix and beta2 and beta3 sheets. The observation of surface hydrophobic clusters reveals a remarkable evolution of the CSalphabeta fold to expose and reorganize hydrophobic residues, which facilitates creating versatile binding sites. | |||
Nuclear magnetic resonance solution structure of Pisum sativum defensin 2 provides evidence for the presence of hydrophobic surface-clusters.,Pinheiro-Aguiar R, do Amaral VSG, Pereira IB, Kurtenbach E, Almeida FCL Proteins. 2019 Jul 11. doi: 10.1002/prot.25783. PMID:31294889<ref>PMID:31294889</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6nom" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Almeida, F C.L]] | |||
[[Category: Amaral, V S.G]] | |||
[[Category: Bastos, I]] | |||
[[Category: Kurtenbach, E]] | |||
[[Category: Pinheiro-Aguiar, R]] | |||
[[Category: Antimicrobial peptide]] | |||
[[Category: Antimicrobial protein]] | |||
[[Category: Plant defensin]] | |||
[[Category: Psd1]] | |||
[[Category: Psd2]] | |||
Revision as of 05:55, 21 August 2019
NMR solution structure of Pisum sativum defensin 2 (Psd2) provides evidence for the presence of hydrophobic surface clusters
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