6qh4: Difference between revisions

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'''Unreleased structure'''


The entry 6qh4 is ON HOLD
==Crystal structure of human Methylmalonyl-CoA epimerase (MCEE) p.Arg143Cys variant==
 
<StructureSection load='6qh4' size='340' side='right' caption='[[6qh4]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
Authors: Bailey, H.J., Chaikuid, A., Krysztofinska, E., Froese, D.S., Sorrell, F.J., Diaz-Saez, L., Kennedy, E., Edwards, A.M., Bountra, C., Yue, W.W.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6qh4]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QH4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QH4 FirstGlance]. <br>
Description: Crystal structure of human Methylmalonyl-CoA epimerase (MCEE) p.Arg143Cys variant
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methylmalonyl-CoA_epimerase Methylmalonyl-CoA epimerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.99.1 5.1.99.1] </span></td></tr>
[[Category: Bailey, H.J]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qh4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qh4 OCA], [http://pdbe.org/6qh4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qh4 RCSB], [http://www.ebi.ac.uk/pdbsum/6qh4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qh4 ProSAT]</span></td></tr>
[[Category: Yue, W.W]]
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/MCEE_HUMAN MCEE_HUMAN]] Vitamin B12-unresponsive methylmalonic acidemia. Methylmalonyl-CoA epimerase deficiency (MCEED) [MIM:[http://omim.org/entry/251120 251120]]: Autosomal recessive inborn error of amino acid metabolism, involving valine, threonine, isoleucine and methionine. This organic aciduria may present in the neonatal period with life-threatening metabolic acidosis, hyperammonemia, feeding difficulties, pancytopenia and coma. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:16752391</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Methylmalonyl-CoA epimerase]]
[[Category: Bailey, H J]]
[[Category: Bountra, C]]
[[Category: Chaikuid, A]]
[[Category: Diaz-Saez, L]]
[[Category: Edwards, A M]]
[[Category: Froese, D S]]
[[Category: Kennedy, E]]
[[Category: Kennedy, E]]
[[Category: Krysztofinska, E]]
[[Category: Krysztofinska, E]]
[[Category: Edwards, A.M]]
[[Category: Sorrell, F J]]
[[Category: Chaikuid, A]]
[[Category: Yue, W W]]
[[Category: Froese, D.S]]
[[Category: Isomerase]]
[[Category: Diaz-Saez, L]]
[[Category: Methylmalonyl-coa epimerase]]
[[Category: Bountra, C]]
[[Category: Mitochondrial]]
[[Category: Sorrell, F.J]]
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