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==Crystal Structure of apo fumarate hydratase from Mycobacterium tuberculosis==
==Crystal Structure of apo fumarate hydratase from Mycobacterium tuberculosis==
<StructureSection load='3no9' size='340' side='right' caption='[[3no9]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
<StructureSection load='3no9' size='340' side='right'caption='[[3no9]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3no9]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NO9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NO9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3no9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NO9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NO9 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fum, fumC, MT1130, MTV017.51c, Rv1098c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.48&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fumarate_hydratase Fumarate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.2 4.2.1.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3no9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3no9 OCA], [https://pdbe.org/3no9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3no9 RCSB], [https://www.ebi.ac.uk/pdbsum/3no9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3no9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3no9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3no9 OCA], [http://pdbe.org/3no9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3no9 RCSB], [http://www.ebi.ac.uk/pdbsum/3no9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3no9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FUMC_MYCTU FUMC_MYCTU]] Catalyzes the reversible addition of water to fumarate to give L-malate.  
[https://www.uniprot.org/uniprot/FUMC_MYCTU FUMC_MYCTU] Catalyzes the reversible addition of water to fumarate to give L-malate.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Fumarate hydratase]]
[[Category: Large Structures]]
[[Category: Myctu]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Hung, L W]]
[[Category: Hung L-W]]
[[Category: Li, H]]
[[Category: Li H]]
[[Category: Sacchettini, J C]]
[[Category: Sacchettini JC]]
[[Category: Swanson, S]]
[[Category: Swanson S]]
[[Category: Structural genomic]]
[[Category: Yu M]]
[[Category: Yu, M]]
[[Category: Apo]]
[[Category: Lyase]]
[[Category: Lyase class i]]
[[Category: Tbsgc]]
[[Category: Tricarboxylic acid cycle]]

Latest revision as of 09:18, 6 September 2023

Crystal Structure of apo fumarate hydratase from Mycobacterium tuberculosis

3no9, resolution 2.48Å

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