6aei: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6aei is ~~ON HOLD until Paper Publication~~

==Cryo-EM structure of the receptor-activated TRPC5 ion channel==

~~Authors~~: ~~Duan~~, J., Li, Z., Li, J.~~, Zhang, J~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[6aei]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AEI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AEI FirstGlance]. <br>

~~Description~~: ~~Cryo~~-~~EM structure of the~~ receptor-activated ~~TRPC5 ion channel~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LPP:2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL+HEXADECANOATE'>LPP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6aei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aei OCA], [http://pdbe.org/6aei PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aei RCSB], [http://www.ebi.ac.uk/pdbsum/6aei PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aei ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/TRPC5_MOUSE TRPC5_MOUSE]] Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion.

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Duan, J]]

[[Category: Li, J]]

[[Category: Li, Z]]

~~[[Category: Li, J]]~~

[[Category: Zhang, J]]

[[Category: Cryo-em]]

[[Category: Ion channel]]

[[Category: Membrane protein]]

[[Category: Mouse trpc5]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6aei is ON HOLD  until Paper Publication
+==Cryo-EM structure of the receptor-activated TRPC5 ion channel==
+<StructureSection load='6aei' size='340' side='right'caption='[[6aei]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
-Authors: Duan, J., Li, Z., Li, J., Zhang, J.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6aei]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AEI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AEI FirstGlance]. <br>
-Description: Cryo-EM structure of the receptor-activated TRPC5 ion channel
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LPP:2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL+HEXADECANOATE'>LPP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6aei FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aei OCA], [http://pdbe.org/6aei PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aei RCSB], [http://www.ebi.ac.uk/pdbsum/6aei PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aei ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/TRPC5_MOUSE TRPC5_MOUSE]] Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion.
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Duan, J]]
+[[Category: Li, J]]
 [[Category: Li, Z]]
-[[Category: Li, J]]
 [[Category: Zhang, J]]
+[[Category: Cryo-em]]
+[[Category: Ion channel]]
+[[Category: Membrane protein]]
+[[Category: Mouse trpc5]]