6h05: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6h05 is ~~ON HOLD~~

==Cryo-electron microscopic structure of the dihydrolipoamide succinyltransferase (E2) component of the human alpha-ketoglutarate (2-oxoglutarate) dehydrogenase complex [residues 218-453]==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[6h05]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H05 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H05 FirstGlance].

~~Description~~:

</td></tr><tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_succinyltransferase Dihydrolipoyllysine-residue succinyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.61 2.3.1.61] </td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h05 OCA], [http://pdbe.org/6h05 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h05 RCSB], [http://www.ebi.ac.uk/pdbsum/6h05 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h05 ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/ODO2_HUMAN ODO2_HUMAN]] Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex (By similarity). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (By similarity). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711).[UniProtKB:Q9N0F1]<ref>PMID:29211711</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Dihydrolipoyllysine-residue succinyltransferase]]

[[Category: Large Structures]]

[[Category: Adam-Vizi, V]]

[[Category: Ambrus, A]]

[[Category: Hubert, A]]

[[Category: Jordan, F]]

[[Category: Nagy, B]]

[[Category: Nemeria, N S]]

[[Category: Novacek, J]]

[[Category: Polak, M]]

[[Category: Zambo, Z]]

[[Category: 2-oxoglutarate dehydrogenase complex]]

[[Category: Alpha-ketoglutarate dehydrogenase complex]]

[[Category: Dihydrolipoamide succinyltransferase]]

[[Category: E2 component]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6h05 is ON HOLD
+==Cryo-electron microscopic structure of the dihydrolipoamide succinyltransferase (E2) component of the human alpha-ketoglutarate (2-oxoglutarate) dehydrogenase complex [residues 218-453]==
+<StructureSection load='6h05' size='340' side='right'caption='[[6h05]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6h05]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H05 FirstGlance]. <br>
-Description:
+</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_succinyltransferase Dihydrolipoyllysine-residue succinyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.61 2.3.1.61] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h05 OCA], [http://pdbe.org/6h05 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h05 RCSB], [http://www.ebi.ac.uk/pdbsum/6h05 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h05 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ODO2_HUMAN ODO2_HUMAN]] Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex (By similarity). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (By similarity). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711).[UniProtKB:Q9N0F1]<ref>PMID:29211711</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Dihydrolipoyllysine-residue succinyltransferase]]
+[[Category: Large Structures]]
+[[Category: Adam-Vizi, V]]
+[[Category: Ambrus, A]]
+[[Category: Hubert, A]]
+[[Category: Jordan, F]]
+[[Category: Nagy, B]]
+[[Category: Nemeria, N S]]
+[[Category: Novacek, J]]
+[[Category: Polak, M]]
+[[Category: Zambo, Z]]
+[[Category: 2-oxoglutarate dehydrogenase complex]]
+[[Category: Alpha-ketoglutarate dehydrogenase complex]]
+[[Category: Dihydrolipoamide succinyltransferase]]
+[[Category: E2 component]]
+[[Category: Transferase]]