6now: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6now is ~~ON HOLD until Paper Publication~~

==Human Alanyl-tRNA Synthetase C-Ala domain==

~~Authors~~: ~~Kuhle~~, B., ~~Schimmel~~, P.

== Structural highlights ==

<table><tr><td colspan='2'>[[6now]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NOW OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NOW FirstGlance].

~~Description~~: ~~Human Alanyl~~-tRNA ~~Synthetase C-~~Ala domain

</td></tr><tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Alanine--tRNA_ligase Alanine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.7 6.1.1.7] </td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6now FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6now OCA], [http://pdbe.org/6now PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6now RCSB], [http://www.ebi.ac.uk/pdbsum/6now PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6now ProSAT]</td></tr>

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/SYAM_HUMAN SYAM_HUMAN]] Combined oxidative phosphorylation defect type 8;Hereditary diffuse leukoencephalopathy with axonal spheroids and pigmented glia;Ovarioleukodystrophy. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[[http://www.uniprot.org/uniprot/SYAM_HUMAN SYAM_HUMAN]] Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.[HAMAP-Rule:MF_03133]

__TOC__

</StructureSection>

[[Category: Alanine--tRNA ligase]]

[[Category: Large Structures]]

[[Category: Kuhle, B]]

[[Category: Schimmel, P]]

[[Category: ~~Kuhle, B~~]]

[[Category: Alanyl-trna synthetase]]

[[Category: Alpha-beta domain]]

[[Category: C-terminal domain]]

[[Category: Ligase]]

[[Category: Mitochondria]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6now is ON HOLD  until Paper Publication
+==Human Alanyl-tRNA Synthetase C-Ala domain==
+<StructureSection load='6now' size='340' side='right'caption='[[6now]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
-Authors: Kuhle, B., Schimmel, P.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6now]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NOW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NOW FirstGlance]. <br>
-Description: Human Alanyl-tRNA Synthetase C-Ala domain
+</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine--tRNA_ligase Alanine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.7 6.1.1.7] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6now FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6now OCA], [http://pdbe.org/6now PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6now RCSB], [http://www.ebi.ac.uk/pdbsum/6now PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6now ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/SYAM_HUMAN SYAM_HUMAN]] Combined oxidative phosphorylation defect type 8;Hereditary diffuse leukoencephalopathy with axonal spheroids and pigmented glia;Ovarioleukodystrophy. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/SYAM_HUMAN SYAM_HUMAN]] Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.[HAMAP-Rule:MF_03133]
+__TOC__
+</StructureSection>
+[[Category: Alanine--tRNA ligase]]
+[[Category: Large Structures]]
+[[Category: Kuhle, B]]
 [[Category: Schimmel, P]]
-[[Category: Kuhle, B]]
+[[Category: Alanyl-trna synthetase]]
+[[Category: Alpha-beta domain]]
+[[Category: C-terminal domain]]
+[[Category: Ligase]]
+[[Category: Mitochondria]]