2qy2: Difference between revisions

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New page: left|200px {{Structure |PDB= 2qy2 |SIZE=350|CAPTION= <scene name='initialview01'>2qy2</scene>, resolution 2.00Å |SITE= <scene name='pdbsite=AC1:Act+Binding+Site+...
 
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[[Image:2qy2.jpg|left|200px]]
[[Image:2qy2.jpg|left|200px]]


{{Structure
<!--
|PDB= 2qy2 |SIZE=350|CAPTION= <scene name='initialview01'>2qy2</scene>, resolution 2.00&Aring;
The line below this paragraph, containing "STRUCTURE_2qy2", creates the "Structure Box" on the page.
|SITE= <scene name='pdbsite=AC1:Act+Binding+Site+For+Residue+A+1002'>AC1</scene> and <scene name='pdbsite=AC2:Act+Binding+Site+For+Residue+A+1003'>AC2</scene>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY=
or leave the SCENE parameter empty for the default display.
|GENE= Refseq YP_142736 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=315393 Mimivirus])
-->
|DOMAIN=
{{STRUCTURE_2qy2| PDB=2qy2  | SCENE= }}  
|RELATEDENTRY=[[2qze|2QZE]], [[3bgy|3BGY]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qy2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qy2 OCA], [http://www.ebi.ac.uk/pdbsum/2qy2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qy2 RCSB]</span>
}}


'''Characterization of a trifunctional mimivirus mRNA capping enzyme and crystal structure of the RNA triphosphatase domainm.'''
'''Characterization of a trifunctional mimivirus mRNA capping enzyme and crystal structure of the RNA triphosphatase domainm.'''


==Overview==
The RNA triphosphatase (RTPase) components of the mRNA capping apparatus are a bellwether of eukaryal taxonomy. Fungal and protozoal RTPases belong to the triphosphate tunnel metalloenzyme (TTM) family, exemplified by yeast Cet1. Several large DNA viruses encode metal-dependent RTPases unrelated to the cysteinyl-phosphatase RTPases of their metazoan host organisms. The origins of DNA virus RTPases are unclear because they are structurally uncharacterized. Mimivirus, a giant virus of amoeba, resembles poxviruses in having a trifunctional capping enzyme composed of a metal-dependent RTPase module fused to guanylyltransferase (GTase) and guanine-N7 methyltransferase domains. The crystal structure of mimivirus RTPase reveals a minimized tunnel fold and an active site strikingly similar to that of Cet1. Unlike homodimeric fungal RTPases, mimivirus RTPase is a monomer. The mimivirus TTM-type RTPase-GTase fusion resembles the capping enzymes of amoebae, providing evidence that the ancestral large DNA virus acquired its capping enzyme from a unicellular host.


==About this Structure==
==About this Structure==
2QY2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mimivirus Mimivirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QY2 OCA].  
2QY2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mimivirus Mimivirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QY2 OCA].  
==Reference==
Characterization of a trifunctional mimivirus mRNA capping enzyme and crystal structure of the RNA triphosphatase domain., Benarroch D, Smith P, Shuman S, Structure. 2008 Apr;16(4):501-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18400173 18400173]
[[Category: Mimivirus]]
[[Category: Mimivirus]]
[[Category: Single protein]]
[[Category: Single protein]]
Line 22: Line 25:
[[Category: Shuman, S.]]
[[Category: Shuman, S.]]
[[Category: Smith, P.]]
[[Category: Smith, P.]]
[[Category: beta tunnel]]
[[Category: Beta tunnel]]
[[Category: hydrolase]]
[[Category: Hydrolase]]
[[Category: mrna capping]]
[[Category: Mrna capping]]
[[Category: mrna processing]]
[[Category: Mrna processing]]
[[Category: multifunctional enzyme]]
[[Category: Multifunctional enzyme]]
[[Category: nucleotidyltransferase]]
[[Category: Nucleotidyltransferase]]
[[Category: phosphatase]]
[[Category: Phosphatase]]
[[Category: s-adenosyl-l-methionine]]
[[Category: S-adenosyl-l-methionine]]
[[Category: transferase]]
[[Category: Transferase]]
[[Category: viral protein]]
[[Category: Viral protein]]
 
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Retrieved from "https://proteopedia.org/2qy2"