6qjd: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry 6qjd is ON HOLD until Paper Publication~~

==Crystal Structure of the truncated form of the third PDZ domain of PSD-95: residues 302-392==

~~Authors: Camara-Artigas, A.~~

== Structural highlights ==

<table><tr><td colspan='2'>[[6qjd]] is a 4 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5ohw 5ohw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QJD OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QJD FirstGlance].

~~Description:~~ Crystal Structure of the truncated form of the third PDZ domain of PSD-95: residues 302-392

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[5ohw|5ohw]]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qjd OCA], [http://pdbe.org/6qjd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qjd RCSB], [http://www.ebi.ac.uk/pdbsum/6qjd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qjd ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Camara-Artigas, A]]

[[Category: Pdz domain]]

[[Category: Signaling protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6qjd is ON HOLD  until Paper Publication
+==Crystal Structure of the truncated form of the third PDZ domain of PSD-95: residues 302-392==
+<StructureSection load='6qjd' size='340' side='right'caption='[[6qjd]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
-Authors: Camara-Artigas, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6qjd]] is a 4 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5ohw 5ohw]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QJD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QJD FirstGlance]. <br>
-Description: Crystal Structure of the truncated form of the third PDZ domain of PSD-95: residues 302-392
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ohw|5ohw]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qjd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qjd OCA], [http://pdbe.org/6qjd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qjd RCSB], [http://www.ebi.ac.uk/pdbsum/6qjd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qjd ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Camara-Artigas, A]]
+[[Category: Pdz domain]]
+[[Category: Signaling protein]]