Cutinase: Difference between revisions
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<StructureSection load='4oyl' size='350' side='right' caption='Structure of cutinase (PDB entry [[4oyl]])' scene='55/551226/Cv/1'> | <StructureSection load='4oyl' size='350' side='right' caption='Structure of cutinase (PDB entry [[4oyl]])' scene='55/551226/Cv/1'> | ||
'''Cutinase''' (CUT) | '''Cutinase''' (CUT) or '''α/β hydrolase family protein''' the conversion of cutin to cutin monomers. Cutin is a main component of the plant cuticle. Polymeric cutin which is composed of hydroxyl and hydroxyepoxy fatty acids is found in the outer layer of plants. CUT is found in fungi and bacteria. CUT degrades the cutin enabling pathogens’ penetration into plant cells. CUT is inhibited by organophosphates like E600 (diethyl-p-nitrophenyl phosphate) and organophosphonates.<ref>PMID:9175860</ref> | ||
== Relevance == | == Relevance == | ||
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Upon CUT inhibition by organophosphates the <scene name='55/551226/Cv/3'>catalytic triad of Ser-His-Asp exhibits esterification of Ser and ethylation of His</scene>.<ref>PMID:24832484</ref> | Upon CUT inhibition by organophosphates the <scene name='55/551226/Cv/3'>catalytic triad of Ser-His-Asp exhibits esterification of Ser and ethylation of His</scene>.<ref>PMID:24832484</ref> | ||
== 3D Structures of cutinase == | |||
[[Cutinase 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
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**[[3gbs]] – CUT – ''Aspergillus oryzae'' <BR /> | **[[3gbs]] – CUT – ''Aspergillus oryzae'' <BR /> | ||
**[[3esc]] – CUT – ''Fusarium solani''<br /> | **[[3esc]] – CUT – ''Fusarium solani''<br /> | ||
**[[4cg1]], [[4cg2]], [[4cg3]] – CUT – ''Thermobifida fusca''<br /> | **[[4cg1]], [[4cg2]], [[4cg3]], [[5zoa]] – CUT – ''Thermobifida fusca''<br /> | ||
**[[4oyy]] – HiCUT – ''Humicola insolens''<BR /> | **[[4oyy]] – HiCUT – ''Humicola insolens''<BR /> | ||
**[[4wfi]], [[4wfj]], [[4wfk]] – | **[[4wfi]], [[4wfj]], [[4wfk]], [[5zrq]], [[5zno]] – SvCUT (mutant) – ''Sacchromonospora viridis''<BR /> | ||
**[[5ajh]] – CUT – ''Fusarium oxysporum''<BR /> | **[[5ajh]] – CUT – ''Fusarium oxysporum''<BR /> | ||
**[[4psc]], [[4psd]] – TrCUT – ''Trichoderma reesei''<BR /> | **[[4psc]], [[4psd]] – TrCUT – ''Trichoderma reesei''<BR /> | ||
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**[[4oyl]] – HiCUT + ethyl phosphate <BR /> | **[[4oyl]] – HiCUT + ethyl phosphate <BR /> | ||
**[[4pse]] – TrCUT + phosphonate derivative<BR /> | **[[4pse]] – TrCUT + phosphonate derivative<BR /> | ||
**[[5zrr]] – SvCUT (mutant) + succinate derivative<BR /> | |||
**[[5zrs]] – SvCUT (mutant) + adipate derivative<BR /> | |||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||
