Dynamin: Difference between revisions

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== Function ==

'''Dynamin''' (DNM) is a GTPase which mediates endocytosis in membrane scission<ref>PMID:22505844</ref> and organelle division. '''Dynamin 1-like''' mediates outer mitochondrial membrane fission<ref>PMID:11703942</ref>. DNM is a multidomain GTPase. Mammalian genomes contain 3 DNM genes which show ca. 80% homology. '''DNM 1''' is localized to neurons, '''DNM 2''' is expressed ubiquitously and '''DNM 3''' is found predominantly in the brain<ref>PMID:22233676</ref>. The DNM 1 domain structure includes GTPase, middle, Plextrin homology, GTPase effector and ~~phophotransferase regulation~~ domains.

'''Dynamin''' (DNM) is a GTPase which mediates endocytosis in membrane scission<ref>PMID:22505844</ref> and organelle division. '''Dynamin 1-like''' mediates outer mitochondrial membrane fission<ref>PMID:11703942</ref>. DNM is a multidomain GTPase. Mammalian genomes contain 3 DNM genes which show ca. 80% homology. '''DNM 1''' is localized to neurons, '''DNM 2''' is expressed ubiquitously and '''DNM 3''' is found predominantly in the brain<ref>PMID:22233676</ref>. The DNM 1 domain structure includes GTPase, middle, Plextrin homology, GTPase effector and proline- and arginine-rich (PRD) domains.

== Disease ==

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+<StructureSection load='5d3q' size='340' side='right' caption='Human dynamin 1 GTPase+GTPase effector domains complex with GDP and ethylene glycol (PDB code [[5d3q]])' scene=''>
-<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
 == Function ==
-'''Dynamin''' (DNM) is a GTPase which mediates endocytosis in membrane scission<ref>PMID:22505844</ref> and organelle division.  '''Dynamin 1-like''' mediates outer mitochondrial membrane fission<ref>PMID:11703942</ref>.  DNM is a multidomain GTPase.  Mammalian genomes contain 3 DNM genes which show ca. 80% homology.  '''DNM 1''' is localized to neurons, '''DNM 2''' is expressed ubiquitously and '''DNM 3''' is found predominantly in the brain<ref>PMID:22233676</ref>.  The DNM 1 domain structure includes GTPase, middle, Plextrin homology, GTPase effector and phophotransferase regulation domains.
+'''Dynamin''' (DNM) is a GTPase which mediates endocytosis in membrane scission<ref>PMID:22505844</ref> and organelle division.  '''Dynamin 1-like''' mediates outer mitochondrial membrane fission<ref>PMID:11703942</ref>.  DNM is a multidomain GTPase.  Mammalian genomes contain 3 DNM genes which show ca. 80% homology.  '''DNM 1''' is localized to neurons, '''DNM 2''' is expressed ubiquitously and '''DNM 3''' is found predominantly in the brain<ref>PMID:22233676</ref>.  The DNM 1 domain structure includes GTPase, middle, Plextrin homology, GTPase effector and proline- and arginine-rich (PRD) domains.
 == Disease ==