6jcd: Difference between revisions
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==G-quadruplex peripheral knot== | |||
<StructureSection load='6jcd' size='340' side='right'caption='[[6jcd]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6jcd]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JCD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JCD FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jcd OCA], [http://pdbe.org/6jcd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jcd RCSB], [http://www.ebi.ac.uk/pdbsum/6jcd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jcd ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
A knot-like G-quadruplex peripheral structure is formed by a 7-nt DNA sequence DL7 (TGTTGGT), in which six out of its seven nucleobases participate in compact base-pairing interactions. Here, the solution NMR structure of a 24-nt DNA oligonucleotide containing the DL7 sequence shows the interaction between a two-layer anti-parallel G-quadruplex core and the peripheral knot-like structure, including the construction of two sharp turns in the DNA backbone. The formation of this novel structural element highlights the intricate properties of single-stranded DNA folding in presence of G-quadruplex-forming motifs. We demonstrated the compatibility of the DL7 knot-like structure with various G-quadruplexes, which could have implications in drug design and DNA engineering. | |||
An Unprecedented Knot-like G-Quadruplex Peripheral Motif.,Truong THA, Winnerdy FR, Phan AT Angew Chem Int Ed Engl. 2019 Jul 17. doi: 10.1002/anie.201907740. PMID:31317601<ref>PMID:31317601</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 6jcd" style="background-color:#fffaf0;"></div> | ||
[[Category: | == References == | ||
[[Category: Winnerdy, F | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Phan, A T]] | |||
[[Category: Truong, T H.A]] | |||
[[Category: Winnerdy, F R]] | |||
[[Category: Diagonal loop]] | |||
[[Category: Dna]] | |||
[[Category: G-quadruplex]] | |||
[[Category: Knot]] | |||
[[Category: Triad]] | |||
Revision as of 15:27, 28 August 2019
G-quadruplex peripheral knot
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