6jh0: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6jh0 is ~~ON HOLD~~

==Crystal structure of cISG15/NS1B complex==

~~Authors~~: ~~Jiang~~, Y.N., ~~Wang~~, X.Q.

== Structural highlights ==

<table><tr><td colspan='2'>[[6jh0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JH0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JH0 FirstGlance]. <br>

~~Description~~: ~~Crystal structure of cISG15~~/~~NS1B complex~~

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jh0 OCA], [http://pdbe.org/6jh0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jh0 RCSB], [http://www.ebi.ac.uk/pdbsum/6jh0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jh0 ProSAT]</span></td></tr>

[[Category: ~~Unreleased~~ Structures]]

</table>

[[Category: Wang, X.Q]]

== Function ==

[[Category: ~~Jiang, Y.N~~]]

[[http://www.uniprot.org/uniprot/NS1_INBLE NS1_INBLE]] Binds and inhibits the ubiquitin-like protein G1P2/ISG15, which is an early antiviral protein. Inhibits IRF-3 nuclear translocation and activation. Inhibits IFN-beta promoter activation; this inhibition is not dsRNA-binding dependent Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.<ref>PMID:15479798</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Jiang, Y N]]

[[Category: Wang, X Q]]

[[Category: Antiviral]]

[[Category: Antiviral protein]]

[[Category: Complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6jh0 is ON HOLD
+==Crystal structure of cISG15/NS1B complex==
+<StructureSection load='6jh0' size='340' side='right'caption='[[6jh0]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-Authors: Jiang, Y.N., Wang, X.Q.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6jh0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JH0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JH0 FirstGlance]. <br>
-Description: Crystal structure of cISG15/NS1B complex
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jh0 OCA], [http://pdbe.org/6jh0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jh0 RCSB], [http://www.ebi.ac.uk/pdbsum/6jh0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jh0 ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Wang, X.Q]]
+== Function ==
-[[Category: Jiang, Y.N]]
+[[http://www.uniprot.org/uniprot/NS1_INBLE NS1_INBLE]] Binds and inhibits the ubiquitin-like protein G1P2/ISG15, which is an early antiviral protein. Inhibits IRF-3 nuclear translocation and activation. Inhibits IFN-beta promoter activation; this inhibition is not dsRNA-binding dependent Prevents EIF2AK2/PKR activation, either by binding double strand RNA or by interacting directly with EIF2AK2/PKR. Also binds poly(A) and U6 snRNA. Suppresses the RNA silencing-based antiviral response in Drosophila cells.<ref>PMID:15479798</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Jiang, Y N]]
+[[Category: Wang, X Q]]
+[[Category: Antiviral]]
+[[Category: Antiviral protein]]
+[[Category: Complex]]