Intrinsically Disordered Protein: Difference between revisions
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* Evasion of immune responses by parasites. Highly flexible disordered proteins are poor antigens <ref>PMID: 23746503</ref>. | * Evasion of immune responses by parasites. Highly flexible disordered proteins are poor antigens <ref>PMID: 23746503</ref>. | ||
* "<b>Molecular shields</b>". It appears that hundreds of IDPs, which remain soluble after boiling, protect folded proteins against heat-denaturation, aggregation, and loss of activity from dessication or organic solvents. They also appear to suppress neurodegeneration and extend lifespan. They have been termed "heat-resistant obscure" (hero) proteins. In several test cases, scrambling the sequences of these proteins did not diminish their protective effects. Thus, | |||
== Protein disorder predictors == | == Protein disorder predictors == | ||
