Sandbox Reserved 1482: Difference between revisions

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“Factor VIII” is an inactive form. The Factor VIII circulates in the bloodstream in this inactive form, bound to another molecule called [[Von Willebrand Factor]], until an injury that damages blood vessels occurs. Indeed, in plasma, factor VIII exists in two forms: free or as a complex with the von Willebrand factor. The complex is the predominant form and exists at a concentration of 0.1 µg/ml in the blood because factor VIII is stabilized by von Willebrand factor, while in its free state, it is rapidly cleaved by [[Serine Proteases]] <ref name="wikipedia" /><ref name="El" />.
“Factor VIII” is an inactive form. The Factor VIII circulates in the bloodstream in this inactive form, bound to another molecule called [[Von Willebrand Factor]], until an injury that damages blood vessels occurs. In plasma, factor VIII exists predominantly in a complex with the Von Willebrand factor, because this latter plays a role of stabilization. By contrast, in its free state, factor VIII is rapidly cleaved by [[Serine Proteases]] <ref name="wikipedia" /><ref name="El" />.




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