6qty: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6qty is ~~ON HOLD until Paper Publication~~

==Non-phosphorylated human CLK1 in complex with an indole inhibitor to 1.65 Ang==

~~Authors~~: ~~Livnah~~, O., ~~Domovich~~, Y.

== Structural highlights ==

<table><tr><td colspan='2'>[[6qty]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QTY OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QTY FirstGlance].

~~Description~~: ~~Non~~-~~phosphorylated human CLK1 in~~ complex ~~with an indole inhibitor~~ to 1.~~65 Ang~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=V25:ETHYL+3-[(E)-2-AMINO-1-CYANOETHENYL]-6,7-DICHLORO-1-METHYL-1H-INDOLE-2-CARBOXYLATE'>V25</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[2vag|2vag]]</td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qty OCA], [http://pdbe.org/6qty PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qty RCSB], [http://www.ebi.ac.uk/pdbsum/6qty PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qty ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/CLK1_HUMAN CLK1_HUMAN]] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.<ref>PMID:10480872</ref> <ref>PMID:19168442</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Dual-specificity kinase]]

[[Category: Large Structures]]

[[Category: Domovich, Y]]

[[Category: Livnah, O]]

[[Category: Clk1]]

[[Category: Kinase]]

[[Category: Signaling protein]]

[[Category: Splicing]]

[[Category: Viral infection]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6qty is ON HOLD  until Paper Publication
+==Non-phosphorylated human CLK1 in complex with an indole inhibitor to 1.65 Ang==
+<StructureSection load='6qty' size='340' side='right'caption='[[6qty]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
-Authors: Livnah, O., Domovich, Y.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6qty]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QTY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QTY FirstGlance]. <br>
-Description: Non-phosphorylated human CLK1 in complex with an indole inhibitor to 1.65 Ang
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=V25:ETHYL+3-[(E)-2-AMINO-1-CYANOETHENYL]-6,7-DICHLORO-1-METHYL-1H-INDOLE-2-CARBOXYLATE'>V25</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vag|2vag]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qty OCA], [http://pdbe.org/6qty PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qty RCSB], [http://www.ebi.ac.uk/pdbsum/6qty PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qty ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CLK1_HUMAN CLK1_HUMAN]] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.<ref>PMID:10480872</ref> <ref>PMID:19168442</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Dual-specificity kinase]]
+[[Category: Large Structures]]
 [[Category: Domovich, Y]]
 [[Category: Livnah, O]]
+[[Category: Clk1]]
+[[Category: Kinase]]
+[[Category: Signaling protein]]
+[[Category: Splicing]]
+[[Category: Viral infection]]