6q3z: Difference between revisions
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==Crystal structure of the first bromodomain of human BRD4 in complex with the inhibitor 16k== | ==Crystal structure of the first bromodomain of human BRD4 in complex with the inhibitor 16k== | ||
<StructureSection load='6q3z' size='340' side='right' | <StructureSection load='6q3z' size='340' side='right'caption='[[6q3z]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6q3z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q3Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q3Z FirstGlance]. <br> | <table><tr><td colspan='2'>[[6q3z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q3Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q3Z FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HG8:(7~{R})-2-[[2-ethoxy-4-(1-methylpiperidin-4-yl)phenyl]amino]-7-ethyl-5-methyl-8-[(4-methylthiophen-2-yl)methyl]-7~{H}-pteridin-6-one'>HG8</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=HG8:(7~{R})-2-[[2-ethoxy-4-(1-methylpiperidin-4-yl)phenyl]amino]-7-ethyl-5-methyl-8-[(4-methylthiophen-2-yl)methyl]-7~{H}-pteridin-6-one'>HG8</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q3z OCA], [http://pdbe.org/6q3z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q3z RCSB], [http://www.ebi.ac.uk/pdbsum/6q3z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q3z ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q3z OCA], [http://pdbe.org/6q3z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q3z RCSB], [http://www.ebi.ac.uk/pdbsum/6q3z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q3z ProSAT]</span></td></tr> | ||
</table> | </table> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
Revision as of 07:13, 27 March 2019
Crystal structure of the first bromodomain of human BRD4 in complex with the inhibitor 16k
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