Sandbox Reserved 1482: Difference between revisions

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 ====Inheritance====
-Hemophilia A is inherited in an X-linked recessive manner. This means that if a son inherits an X chromosome carrying hemophilia from his mother, he will have hemophilia. By contrast, daughters, even if they inherit the hemophilia gene from their mother, they inherit a healthy X chromosome from their father. As a result, they are only carriers but not affected.
+Hemophilia A is inherited in an X-linked recessive manner. This means that if a son inherits an X chromosome carrying hemophilia from his mother, he will have hemophilia. By contrast, daughters, even if they inherit one hemophilia allele, they can compensate it with their second healthy X chromosome. As a result, women only rarely have symptoms, but women that are carriers, may pass the gene on to their children (50% chance per pregnancy) <ref name="Konkle" />.
-Thus, because of the recessivity only men are affected by this disease and women are carriers that may pass the gene on to their children (50% chance of transmitting it in each pregnancy). <ref name="Srivastava" />
-The risk for boys to carry the disease therefore depends on the carrier status of the mother because affected males transmit the pathogenic variant to all of their daughters and none of their sons <ref name="Konkle" />.

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