6n3g: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6n3g is ~~ON HOLD until Paper Publication~~

==Crystal structure of histone lysine methyltransferase SmyD2 in complex with polyethylene glycol==

~~Authors~~: ~~Perry~~, E., ~~Spellmon~~, N., ~~Brunzelle~~, J.~~, Yang, Z~~.

== Structural highlights ==

<table><tr><td colspan='2'>[[6n3g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N3G FirstGlance]. <br>

~~Description~~: ~~Crystal structure of~~ histone ~~lysine~~ methyltransferase ~~SmyD2 in complex with polyethylene glycol~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n3g OCA], [http://pdbe.org/6n3g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n3g RCSB], [http://www.ebi.ac.uk/pdbsum/6n3g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n3g ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/SMYD2_HUMAN SMYD2_HUMAN]] Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB.<ref>PMID:17108971</ref> <ref>PMID:17805299</ref> <ref>PMID:18065756</ref> <ref>PMID:20870719</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Brunzelle, J]]

[[Category: Perry, E]]

[[Category: Spellmon, N]]

[[Category: Yang, Z]]

[[Category: ~~Spellmon, N~~]]

[[Category: Complex]]

[[Category: ~~Perry, E~~]]

[[Category: Methyltransferase]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6n3g is ON HOLD  until Paper Publication
+==Crystal structure of histone lysine methyltransferase SmyD2 in complex with polyethylene glycol==
+<StructureSection load='6n3g' size='340' side='right'caption='[[6n3g]], [[Resolution|resolution]] 2.43&Aring;' scene=''>
-Authors: Perry, E., Spellmon, N., Brunzelle, J., Yang, Z.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6n3g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N3G FirstGlance]. <br>
-Description: Crystal structure of histone lysine methyltransferase SmyD2 in complex with polyethylene glycol
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n3g OCA], [http://pdbe.org/6n3g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n3g RCSB], [http://www.ebi.ac.uk/pdbsum/6n3g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n3g ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/SMYD2_HUMAN SMYD2_HUMAN]] Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). Has also methyltransferase activity toward non-histone proteins such as p53/TP53 and RB1. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates 'Lys-860' of RB1/RB.<ref>PMID:17108971</ref> <ref>PMID:17805299</ref> <ref>PMID:18065756</ref> <ref>PMID:20870719</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Brunzelle, J]]
+[[Category: Perry, E]]
+[[Category: Spellmon, N]]
 [[Category: Yang, Z]]
-[[Category: Spellmon, N]]
+[[Category: Complex]]
-[[Category: Perry, E]]
+[[Category: Methyltransferase]]
+[[Category: Transferase]]