6qwv: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6qwv is ~~ON HOLD until Paper Publication~~

==SARM1 SAM1-2 domains==

~~Authors~~: ~~Sporny~~, M., ~~Isupov~~, N.M., ~~Opatowsky~~, Y.

== Structural highlights ==

<table><tr><td colspan='2'>[[6qwv]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QWV FirstGlance]. <br>

~~Description~~: signaling ~~protein~~

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qwv OCA], [http://pdbe.org/6qwv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qwv RCSB], [http://www.ebi.ac.uk/pdbsum/6qwv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qwv ProSAT]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/SARM1_HUMAN SARM1_HUMAN]] Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.<ref>PMID:15123841</ref> <ref>PMID:16964262</ref> <ref>PMID:16985498</ref> <ref>PMID:20306472</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Isupov, N M]]

[[Category: Opatowsky, Y]]

[[Category: Sporny, M]]

[[Category: ~~Isupov, N.M~~]]

[[Category: Apoptosis]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6qwv is ON HOLD  until Paper Publication
+==SARM1 SAM1-2 domains==
+<StructureSection load='6qwv' size='340' side='right'caption='[[6qwv]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
-Authors: Sporny, M., Isupov, N.M., Opatowsky, Y.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6qwv]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QWV FirstGlance]. <br>
-Description: signaling protein
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qwv OCA], [http://pdbe.org/6qwv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qwv RCSB], [http://www.ebi.ac.uk/pdbsum/6qwv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qwv ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/SARM1_HUMAN SARM1_HUMAN]] Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.<ref>PMID:15123841</ref> <ref>PMID:16964262</ref> <ref>PMID:16985498</ref> <ref>PMID:20306472</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Isupov, N M]]
 [[Category: Opatowsky, Y]]
 [[Category: Sporny, M]]
-[[Category: Isupov, N.M]]
+[[Category: Apoptosis]]