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<StructureSection load='6hoh' size='340' side='right'caption='[[6hoh]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='6hoh' size='340' side='right'caption='[[6hoh]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6hoh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HOH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HOH FirstGlance]. <br>
<table><tr><td colspan='2'>[[6hoh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HOH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GABARAP, FLC3B, HT004 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hoh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hoh OCA], [https://pdbe.org/6hoh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hoh RCSB], [https://www.ebi.ac.uk/pdbsum/6hoh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hoh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hoh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hoh OCA], [http://pdbe.org/6hoh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hoh RCSB], [http://www.ebi.ac.uk/pdbsum/6hoh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hoh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN]] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref>
[https://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref> [https://www.uniprot.org/uniprot/GBRAP_HUMAN GBRAP_HUMAN] May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy (By similarity).<ref>PMID:15977068</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6hoh" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6hoh" style="background-color:#fffaf0;"></div>
==See Also==
*[[GABA receptor-associated protein 3D structures|GABA receptor-associated protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Phosphatidylinositol 3-kinase]]
[[Category: Bhujbal Z]]
[[Category: Bhujbal, Z]]
[[Category: Birgisdottir AB]]
[[Category: Birgisdottir, A B]]
[[Category: Evjen G]]
[[Category: Evjen, G]]
[[Category: Johansen T]]
[[Category: Johansen, T]]
[[Category: Lamark T]]
[[Category: Lamark, T]]
[[Category: Lee R]]
[[Category: Lee, R]]
[[Category: Mouilleron S]]
[[Category: Mouilleron, S]]
[[Category: O'Reilly N]]
[[Category: Reilly, N O]]
[[Category: Sjottem E]]
[[Category: Sjottem, E]]
[[Category: Tooze S]]
[[Category: Tooze, S]]
[[Category: Wirth M]]
[[Category: Wirth, M]]
[[Category: Zhang W]]
[[Category: Zhang, W]]
[[Category: Atg8]]
[[Category: Autophagy]]
[[Category: Lir]]
[[Category: Signaling protein]]
Retrieved from "https://proteopedia.org/6hoh"