Ficolin

spinqualitylabelsall models Human H-ficolin binding domain trimer complex with Ca+2 ion (PDB code 2j64) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Ficolin (Fic) are defense proteins which belong to the innate immune system and recognize carbohydrate molecules. 3 ficolins were identified in humans L-Fic or ficolin-2, H-Fic or ficolin-3 and M-Fic or ficolin-1. 'ficolin-1 or M-ficolin is a pattern recognition molecule of the complement system expressed in myeloid cells. Disease Fn may play a role in inflammatory diseases, apoptosis, lupus, preeclampsia and IgA nephropathy. Structural highlights Human H-ficolin binding domain trimer. Ca coordination site (PDB code 2j64). Water molecules shown as red spheres.

3D Structures of Ficolin

Updated on 23-June-2024

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• H-ficolin
  • 2j64 - hH-Fic binding domain - human
    
  • 2j5z - hH-Fic binding domain + galactose
    
  • 2j60 - hH-Fic binding domain + fucose
    
  • 2j61 - hH-Fic binding domain + acetyl-glucosamine
    
• L-ficolin
  • 2j3g, 4r9t - hL-Fic binding domain
    
  • 2j0g – hL-Fic binding domain + N-acetyl-mannosamine
    
  • 2j0h - hL-Fic binding domain + acetylcholine
    
  • 4nyt - hL-Fic binding domain + phosphocholine
    
  • 2j0y - hL-Fic binding domain + glucan
    
  • 2j1g, 2j2p - hL-Fic binding domain + acetylcysteine
    
  • 2j3f - hL-Fic binding domain + galactosamine
    
  • 2j3o - hL-Fic binding domain + acetyl-glucosamine
    
  • 4r9j - hL-Fic binding domain + glucosamine sulfate
    
  • 2j3u - hL-Fic binding domain + galactose
    
• M-ficolin
  • 2d39 – hM-Fic fibrinogen-like domain
    
  • 2wnp - hM-Fic fibrinogen-like domain (mutant)
    
  • 2jhh, 2jhm – hM-Fic C terminal
    
  • 2jhi - hL-Mic C terminal + acetyl-galactosamine
    
  • 2jhk - hL-Mic C terminal + acetyl-glucosamine
    
  • 2jhl - hL-Mic C terminal + sialic acid

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Michal Harel, Alexander Berchansky