4cql: Difference between revisions

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<StructureSection load='4cql' size='340' side='right'caption='[[4cql]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
<StructureSection load='4cql' size='340' side='right'caption='[[4cql]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4cql]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CQL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CQL FirstGlance]. <br>
<table><tr><td colspan='2'>[[4cql]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CQL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CQL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cqm|4cqm]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cql OCA], [https://pdbe.org/4cql PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cql RCSB], [https://www.ebi.ac.uk/pdbsum/4cql PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cql ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-oxoacyl-[acyl-carrier-protein]_reductase 3-oxoacyl-[acyl-carrier-protein] reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.100 1.1.1.100] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cql FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cql OCA], [http://pdbe.org/4cql PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4cql RCSB], [http://www.ebi.ac.uk/pdbsum/4cql PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4cql ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DHB8_HUMAN DHB8_HUMAN]] NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria.<ref>PMID:17978863</ref> <ref>PMID:19571038</ref> [[http://www.uniprot.org/uniprot/CBR4_HUMAN CBR4_HUMAN]] The heteroteramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent quinone reductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro).<ref>PMID:19000905</ref> <ref>PMID:19571038</ref> 
[[https://www.uniprot.org/uniprot/DHB8_HUMAN DHB8_HUMAN]] NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria.<ref>PMID:17978863</ref> <ref>PMID:19571038</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Carbonyl reductase|Carbonyl reductase]]
*[[Carbonyl reductase 3D structures|Carbonyl reductase 3D structures]]
*[[Hydroxysteroid dehydrogenase|Hydroxysteroid dehydrogenase]]
*[[Hydroxysteroid dehydrogenase 3D structures|Hydroxysteroid dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Awoniyi, L O]]
[[Category: Awoniyi LO]]
[[Category: Chen, Z]]
[[Category: Chen Z]]
[[Category: Hiltunen, J K]]
[[Category: Hiltunen JK]]
[[Category: Jiang, G]]
[[Category: Jiang G]]
[[Category: Kastaniotis, A J]]
[[Category: Kastaniotis AJ]]
[[Category: Prus, P]]
[[Category: Prus P]]
[[Category: Sah-Teli, S K]]
[[Category: Sah-Teli SK]]
[[Category: Venkatesan, R]]
[[Category: Venkatesan R]]
[[Category: Wierenga, R K]]
[[Category: Wierenga RK]]
[[Category: 17-beta hydroxysteroid dehydrogenase]]
[[Category: 3-ketoacyl-acp reductase]]
[[Category: 3r- hydroxyacyl-coa dehydrogenase]]
[[Category: Carbobyl reductase type4]]
[[Category: Hetero tetramer]]
[[Category: Hsd17b8]]
[[Category: Hsd8]]
[[Category: Kar]]
[[Category: Nadh]]
[[Category: Nadp]]
[[Category: Nadph]]
[[Category: Oxidoreductase]]
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