5zgc: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 5zgc is ~~ON HOLD until Paper Publication~~

==Crystal Structure of SIRT3 in complex with H4K16bhb peptide==

~~Authors~~: Li, H., ~~Zhang~~, X.

== Structural highlights ==

<table><tr><td colspan='2'>[[5zgc]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZGC OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZGC FirstGlance].

~~Description~~: ~~Crystal Structure~~ of ~~SIRT3 in complex with H4K16bhb peptide~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=KHB:'>KHB</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zgc OCA], [http://pdbe.org/5zgc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zgc RCSB], [http://www.ebi.ac.uk/pdbsum/5zgc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zgc ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/SIR3_HUMAN SIR3_HUMAN]] NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.<ref>PMID:16788062</ref> <ref>PMID:18680753</ref> <ref>PMID:18794531</ref> <ref>PMID:19535340</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Li, H]]

[[Category: Zhang, X]]

[[Category: Hydrolase]]

[[Category: Rossmann fold]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 5zgc is ON HOLD  until Paper Publication
+==Crystal Structure of SIRT3 in complex with H4K16bhb peptide==
+<StructureSection load='5zgc' size='340' side='right'caption='[[5zgc]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-Authors: Li, H., Zhang, X.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5zgc]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZGC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZGC FirstGlance]. <br>
-Description: Crystal Structure of SIRT3 in complex with H4K16bhb peptide
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=KHB:'>KHB</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zgc OCA], [http://pdbe.org/5zgc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zgc RCSB], [http://www.ebi.ac.uk/pdbsum/5zgc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zgc ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/SIR3_HUMAN SIR3_HUMAN]] NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.<ref>PMID:16788062</ref> <ref>PMID:18680753</ref> <ref>PMID:18794531</ref> <ref>PMID:19535340</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Li, H]]
 [[Category: Zhang, X]]
+[[Category: Hydrolase]]
+[[Category: Rossmann fold]]