6oba: Difference between revisions

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'''Unreleased structure'''


The entry 6oba is ON HOLD  until Paper Publication
==The beta2 adrenergic receptor bound to a negative allosteric modulator==
 
<StructureSection load='6oba' size='340' side='right'caption='[[6oba]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
Authors: Liu, X., Stobel, A., Kaindl, J., Dengler, D., ClarK, M., Mahoney, J., Korczynska, M., Matt, R.A., Hubner, H., Xu, X., Stanek, M., Hirata, K., Shoichet, B., Sunahara, R., Gmeiner, R., Kobilka, B.K.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6oba]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OBA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OBA FirstGlance]. <br>
Description: The beta2 adrenergic receptor bound to a negative allosteric modulator
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=JTZ:(2S)-1-[(1-METHYLETHYL)AMINO]-3-(2-PROP-2-EN-1-YLPHENOXY)PROPAN-2-OL'>JTZ</scene>, <scene name='pdbligand=M3J:6-bromo-N~2~-phenylquinazoline-2,4-diamine'>M3J</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
[[Category: Clark, M]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6oba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oba OCA], [http://pdbe.org/6oba PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oba RCSB], [http://www.ebi.ac.uk/pdbsum/6oba PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oba ProSAT]</span></td></tr>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Lysozyme]]
[[Category: ClarK, M]]
[[Category: Dengler, D]]
[[Category: Gmeiner, R]]
[[Category: Hirata, K]]
[[Category: Hubner, H]]
[[Category: Hubner, H]]
[[Category: Kaindl, J]]
[[Category: Kaindl, J]]
[[Category: Kobilka, B K]]
[[Category: Korczynska, M]]
[[Category: Korczynska, M]]
[[Category: Gmeiner, R]]
[[Category: Liu, X]]
[[Category: Liu, X]]
[[Category: Mahoney, J]]
[[Category: Matt, R A]]
[[Category: Shoichet, B]]
[[Category: Shoichet, B]]
[[Category: Matt, R.A]]
[[Category: Stanek, M]]
[[Category: Stanek, M]]
[[Category: Stobel, A]]
[[Category: Stobel, A]]
[[Category: Mahoney, J]]
[[Category: Sunahara, R]]
[[Category: Hirata, K]]
[[Category: Xu, X]]
[[Category: Xu, X]]
[[Category: Dengler, D]]
[[Category: Allosteric modulator]]
[[Category: Sunahara, R]]
[[Category: G protein coupled receptor]]
[[Category: Kobilka, B.K]]
[[Category: Membrane protein]]
[[Category: Signal transduction]]
[[Category: Signaling protein]]
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