4f8v: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f8v OCA], [http://pdbe.org/4f8v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4f8v RCSB], [http://www.ebi.ac.uk/pdbsum/4f8v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4f8v ProSAT]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

Sisomicin with an unsaturated sugar ring I displays better antibacterial activity than other structurally related aminoglycosides, such as gentamicin, tobramycin, and amikacin. In the present study, we have confirmed by X-ray analyses that the binding mode of sisomicin is basically similar but not identical to that of the related compounds having saturated ring I. A remarkable difference is found in the stacking interaction between ring I and G1491. While the typical saturated ring I with a chair conformation stacks on G1491 through CH/pi interactions, the unsaturated ring I of sisomicin with a partially planar conformation can share its pi-electron density with G1491 and fits well within the A-site helix.

Crystal structure and specific binding mode of sisomicin to the bacterial ribosomal decoding site.,Kondo J, Koganei M, Kasahara T ACS Med Chem Lett. 2012 Aug 2;3(9):741-4. doi: 10.1021/ml300145y. eCollection, 2012 Sep 13. PMID:24900542<ref>PMID:24900542</ref>

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

== References ==

__TOC__

</StructureSection>

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@@ Line 8: / Line 8: @@
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f8v OCA], [http://pdbe.org/4f8v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4f8v RCSB], [http://www.ebi.ac.uk/pdbsum/4f8v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4f8v ProSAT]</span></td></tr>
 </table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Sisomicin with an unsaturated sugar ring I displays better antibacterial activity than other structurally related aminoglycosides, such as gentamicin, tobramycin, and amikacin. In the present study, we have confirmed by X-ray analyses that the binding mode of sisomicin is basically similar but not identical to that of the related compounds having saturated ring I. A remarkable difference is found in the stacking interaction between ring I and G1491. While the typical saturated ring I with a chair conformation stacks on G1491 through CH/pi interactions, the unsaturated ring I of sisomicin with a partially planar conformation can share its pi-electron density with G1491 and fits well within the A-site helix.
+Crystal structure and specific binding mode of sisomicin to the bacterial ribosomal decoding site.,Kondo J, Koganei M, Kasahara T ACS Med Chem Lett. 2012 Aug 2;3(9):741-4. doi: 10.1021/ml300145y. eCollection, 2012 Sep 13. PMID:24900542<ref>PMID:24900542</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 4f8v" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
 __TOC__
 </StructureSection>