4i0k: Difference between revisions

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<StructureSection load='4i0k' size='340' side='right'caption='[[4i0k]], [[Resolution|resolution]] 2.97&Aring;' scene=''>
<StructureSection load='4i0k' size='340' side='right'caption='[[4i0k]], [[Resolution|resolution]] 2.97&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4i0k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I0K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I0K FirstGlance]. <br>
<table><tr><td colspan='2'>[[4i0k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I0K FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">B7-H3, B7h3, Cd276 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i0k OCA], [https://pdbe.org/4i0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i0k RCSB], [https://www.ebi.ac.uk/pdbsum/4i0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i0k ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i0k OCA], [http://pdbe.org/4i0k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4i0k RCSB], [http://www.ebi.ac.uk/pdbsum/4i0k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4i0k ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CD276_MOUSE CD276_MOUSE]] Modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection. Plays a positive regulatory role in bone formation and has a dual role in the bone-immune interface. Induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T-cell dependent killing of tumor cells.<ref>PMID:12055244</ref> <ref>PMID:12925852</ref> <ref>PMID:12939639</ref> <ref>PMID:15294965</ref> <ref>PMID:15682454</ref>
[https://www.uniprot.org/uniprot/CD276_MOUSE CD276_MOUSE] Modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection. Plays a positive regulatory role in bone formation and has a dual role in the bone-immune interface. Induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T-cell dependent killing of tumor cells.<ref>PMID:12055244</ref> <ref>PMID:12925852</ref> <ref>PMID:12939639</ref> <ref>PMID:15294965</ref> <ref>PMID:15682454</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Almo, S C]]
[[Category: Almo SC]]
[[Category: Bonanno, J B]]
[[Category: Bonanno JB]]
[[Category: IFN, Atoms-to-Animals:.The Immune Function Network]]
[[Category: Nathenson SG]]
[[Category: Structural genomic]]
[[Category: Ramagopal U]]
[[Category: Nathenson, S G]]
[[Category: Toro R]]
[[Category: Ramagopal, U]]
[[Category: Vigdorovich V]]
[[Category: Toro, R]]
[[Category: Vigdorovich, V]]
[[Category: Adaptive immunity]]
[[Category: Atoms-to-animals: the immune function network]]
[[Category: Cell surface]]
[[Category: Glycoprotein]]
[[Category: Ifn]]
[[Category: Immune system]]
[[Category: Immunity]]
[[Category: Immunoglobulin constant like domain]]
[[Category: Immunoglobulin domain]]
[[Category: Immunoglobulin variable like domain]]
[[Category: Nysgrc]]
[[Category: PSI, Protein structure initiative]]
[[Category: Psi-biology]]

Revision as of 08:31, 9 November 2022

Crystal structure of murine B7-H3 extracellular domain

4i0k, resolution 2.97Å

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