2vnu: Difference between revisions

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[[Image:2vnu.jpg|left|200px]]
{{Seed}}
[[Image:2vnu.png|left|200px]]


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{{STRUCTURE_2vnu|  PDB=2vnu  |  SCENE=  }}  
{{STRUCTURE_2vnu|  PDB=2vnu  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF SC RRP44'''
===CRYSTAL STRUCTURE OF SC RRP44===




==Overview==
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The eukaryotic exosome is a macromolecular complex essential for RNA processing and decay. It has recently been shown that the RNase activity of the yeast exosome core can be mapped to a single subunit, Rrp44, which processively degrades single-stranded RNAs as well as RNAs containing secondary structures. Here we present the 2.3 A resolution crystal structure of S. cerevisiae Rrp44 in complex with single-stranded RNA. Although Rrp44 has a linear domain organization similar to bacterial RNase II, in three dimensions the domains have a different arrangement. The three domains of the classical nucleic-acid-binding OB fold are positioned on the catalytic domain such that the RNA-binding path observed in RNase II is occluded. Instead, RNA is threaded to the catalytic site via an alternative route suggesting a mechanism for RNA-duplex unwinding. The structure provides a molecular rationale for the observed biochemical properties of the RNase R family of nucleases.
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{{ABSTRACT_PUBMED_18374646}}


==About this Structure==
==About this Structure==
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[[Category: Rrna processing]]
[[Category: Rrna processing]]
[[Category: Rrp44]]
[[Category: Rrp44]]
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