6r5y: Difference between revisions
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==8-bladed beta-propeller formed by two 4-bladed fragments== | |||
<StructureSection load='6r5y' size='340' side='right'caption='[[6r5y]], [[Resolution|resolution]] 2.15Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6r5y]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R5Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R5Y FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r5y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r5y OCA], [http://pdbe.org/6r5y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r5y RCSB], [http://www.ebi.ac.uk/pdbsum/6r5y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r5y ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
beta-Propellers arise through the amplification of a supersecondary structure element called a blade. This process produces toroids of between four and twelve repeats, which are almost always arranged sequentially in a single polypeptide chain. We found that new propellers evolve continuously by amplification from single blades. We therefore investigated whether such nascent propellers can fold as homo-oligomers before they have been fully amplified within a single chain. One- to six-bladed building blocks derived from two seven-bladed WD40 propellers yielded stable homo-oligomers with six to nine blades, depending on the size of the building block. High-resolution structures for tetramers of two blades, trimers of three blades, and dimers of four and five blades, respectively, show structurally diverse propellers and include a novel fold, highlighting the inherent flexibility of the WD40 blade. Our data support the hypothesis that subdomain-sized fragments can provide structural versatility in the evolution of new proteins. | |||
Structural diversity of oligomeric beta-propellers with different numbers of identical blades.,Afanasieva E, Chaudhuri I, Martin J, Hertle E, Ursinus A, Alva V, Hartmann MD, Lupas AN Elife. 2019 Oct 15;8. pii: 49853. doi: 10.7554/eLife.49853. PMID:31613220<ref>PMID:31613220</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6r5y" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Hartmann, M D]] | |||
[[Category: Lupas, A N]] | |||
[[Category: Martin, J]] | |||
[[Category: Fragment amplification]] | |||
[[Category: Protein design]] | |||
[[Category: Protein evolution]] | |||
[[Category: Repeat protein]] | |||
[[Category: Unknown function]] | |||
Revision as of 11:11, 13 November 2019
8-bladed beta-propeller formed by two 4-bladed fragments
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