5nvr: Difference between revisions

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<StructureSection load='5nvr' size='340' side='right'caption='[[5nvr]], [[Resolution|resolution]] 3.95&Aring;' scene=''>
<StructureSection load='5nvr' size='340' side='right'caption='[[5nvr]], [[Resolution|resolution]] 3.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5nvr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NVR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NVR FirstGlance]. <br>
<table><tr><td colspan='2'>[[5nvr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NVR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NVR FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.95&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RIF1, YBR275C, YBR1743 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nvr OCA], [http://pdbe.org/5nvr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nvr RCSB], [http://www.ebi.ac.uk/pdbsum/5nvr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nvr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nvr OCA], [https://pdbe.org/5nvr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nvr RCSB], [https://www.ebi.ac.uk/pdbsum/5nvr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nvr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RIF1_YEAST RIF1_YEAST]] Negatively regulates telomere length by preventing telomere elongation or promoting degradation of the telomere ends. Recruited to telomeres by interaction with the C-terminus of RAP1, which binds directly to telomeric repeat DNA. This may create a negative feedback loop in which the addition of new telomere repeats creates binding sites for inhibitors of telomere length extension. May also influence the balance of transcriptional silencing at telomeres and the silent mating type locus HMR, which is mediated by SIR (Silent Information Regulator) proteins including SIR3 and SIR4. RIF1 competes with SIR proteins for binding to the C-terminus of RAP1. In the absence of RIF1, a limiting cellular pool of SIR proteins may preferentially associate with RAP1 at sub-telomeric loci, causing enhanced telomeric silencing and attenuated silencing of the HMR locus.<ref>PMID:1577274</ref> <ref>PMID:7867933</ref> <ref>PMID:9087429</ref> <ref>PMID:10531008</ref> <ref>PMID:15572688</ref>
[https://www.uniprot.org/uniprot/RIF1_YEAST RIF1_YEAST] Negatively regulates telomere length by preventing telomere elongation or promoting degradation of the telomere ends. Recruited to telomeres by interaction with the C-terminus of RAP1, which binds directly to telomeric repeat DNA. This may create a negative feedback loop in which the addition of new telomere repeats creates binding sites for inhibitors of telomere length extension. May also influence the balance of transcriptional silencing at telomeres and the silent mating type locus HMR, which is mediated by SIR (Silent Information Regulator) proteins including SIR3 and SIR4. RIF1 competes with SIR proteins for binding to the C-terminus of RAP1. In the absence of RIF1, a limiting cellular pool of SIR proteins may preferentially associate with RAP1 at sub-telomeric loci, causing enhanced telomeric silencing and attenuated silencing of the HMR locus.<ref>PMID:1577274</ref> <ref>PMID:7867933</ref> <ref>PMID:9087429</ref> <ref>PMID:10531008</ref> <ref>PMID:15572688</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Baker's yeast]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bunker, R D]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Shi, T]]
[[Category: Bunker RD]]
[[Category: Thoma, N H]]
[[Category: Shi T]]
[[Category: All-alpha fold]]
[[Category: Thoma NH]]
[[Category: Dna double-strand break repair]]
[[Category: Irregular helical repeat]]
[[Category: Structural protein]]
[[Category: Telomere maintenance]]
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