6fne: Difference between revisions

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==Structure of Brag2==

==Structure of human Brag2 (Sec7-PH domains) with the inhibitor Bragsin bound to the PH domain==

== Structural highlights ==

<table><tr><td colspan='2'>[[6fne]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FNE OCA]. For a guided tour on the structure components use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6FNE FirstGlance].

<table><tr><td colspan='2'>[[6fne]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FNE OCA]. For a guided tour on the structure components use [http://proteopedia.org/fgij/fg.htm?mol=6FNE FirstGlance].

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=DY5:(2~{S})-6-methyl-5-nitro-2-(trifluoromethyl)-2,3-dihydrochromen-4-one'>DY5</scene></td></tr>

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=DY5:(2~{S})-6-methyl-5-nitro-2-(trifluoromethyl)-2,3-dihydrochromen-4-one'>DY5</scene></td></tr>

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">IQSEC1, ARFGEP100, BRAG2, KIAA0763 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6fne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fne OCA], [http://pdbe.org/6fne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fne RCSB], [http://www.ebi.ac.uk/pdbsum/6fne PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fne ProSAT]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://proteopedia.org/fgij/fg.htm?mol=6fne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fne OCA], [http://pdbe.org/6fne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fne RCSB], [http://www.ebi.ac.uk/pdbsum/6fne PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fne ProSAT]</td></tr>

</table>

== Function ==

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-==Structure of Brag2==
+==Structure of human Brag2 (Sec7-PH domains) with the inhibitor Bragsin bound to the PH domain==
 <StructureSection load='6fne' size='340' side='right'caption='[[6fne]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6fne]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FNE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FNE FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6fne]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FNE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6FNE FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=DY5:(2~{S})-6-methyl-5-nitro-2-(trifluoromethyl)-2,3-dihydrochromen-4-one'>DY5</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2PE:NONAETHYLENE+GLYCOL'>2PE</scene>, <scene name='pdbligand=DY5:(2~{S})-6-methyl-5-nitro-2-(trifluoromethyl)-2,3-dihydrochromen-4-one'>DY5</scene></td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IQSEC1, ARFGEP100, BRAG2, KIAA0763 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fne OCA], [http://pdbe.org/6fne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fne RCSB], [http://www.ebi.ac.uk/pdbsum/6fne PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fne ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6fne FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fne OCA], [http://pdbe.org/6fne PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fne RCSB], [http://www.ebi.ac.uk/pdbsum/6fne PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fne ProSAT]</span></td></tr>
 </table>
 == Function ==