4klz: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 3: | Line 3: | ||
<StructureSection load='4klz' size='340' side='right'caption='[[4klz]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='4klz' size='340' side='right'caption='[[4klz]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4klz]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4klz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KLZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KLZ FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4klz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4klz OCA], [https://pdbe.org/4klz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4klz RCSB], [https://www.ebi.ac.uk/pdbsum/4klz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4klz ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/RIT1_HUMAN RIT1_HUMAN] Noonan syndrome. The disease is caused by mutations affecting the gene represented in this entry. | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/RIT1_HUMAN RIT1_HUMAN] Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation.<ref>PMID:15632082</ref> <ref>PMID:23791108</ref> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ab | [[Category: Ab E]] | ||
[[Category: Andrews | [[Category: Andrews M]] | ||
[[Category: Hoedemaeker | [[Category: Hoedemaeker FJ]] | ||
[[Category: Keizers | [[Category: Keizers PH]] | ||
[[Category: Kobayashi | [[Category: Kobayashi M]] | ||
[[Category: Manning | [[Category: Manning L]] | ||
[[Category: Rzepiela | [[Category: Rzepiela AA]] | ||
[[Category: Shah | [[Category: Shah DM]] | ||
[[Category: Siegal | [[Category: Siegal G]] | ||
[[Category: Tuin | [[Category: Tuin AW]] | ||
Revision as of 08:58, 7 December 2022
Inhibition of Small GTPases by Stabilization of the GDP Complex, a Novel Approach applied to Rit1, a Target for Rheumatoid Arthritis
| ||||||||||||
