Paclitaxel: Difference between revisions

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==History==

It was first discovered in a US National Cancer Institute program in 1962. Monroe E. Wall and Mansukh C. Wani isolated it from the bark of a Pacific yew tree. Upon doing more research, they discovered that endophytic fungi in the bark of the tree synthesize paclitaxel. In 1977, scientists were able to confirm antitumor activity in mouse melanoma. During this year, Dr. Susan Horwitz discovered that paclitaxel was able to bind to a cell’s microtubule assembly and slow or cease cell division and growth. Ever since 1992, paclitaxel has been used for the treatment of various cancers. <ref>“Horwitz, Susan. “Taxol® (NSC 125973).” National Cancer Institute, dtp.cancer.gov/timeline/flash/success_stories/s2_taxol.htm.</ref>

Paclitaxel was first discovered in a US National Cancer Institute program in 1962. Monroe E. Wall and Mansukh C. Wani isolated it from the bark of a Pacific yew tree. Upon doing more research, they discovered that endophytic fungi in the bark of the tree synthesize paclitaxel. In 1977, scientists were able to confirm antitumor activity in mouse melanoma. During this year, Dr. Susan Horwitz discovered that paclitaxel was able to bind to a cell’s microtubule assembly and slow or cease cell division and growth. Ever since 1992, paclitaxel has been used for the treatment of various cancers. <ref>“Horwitz, Susan. “Taxol® (NSC 125973).” National Cancer Institute, dtp.cancer.gov/timeline/flash/success_stories/s2_taxol.htm.</ref>

==Structure==

Paclitaxel: Difference between revisions

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@@ Line 7: / Line 7: @@
 ==History==
-It was first discovered in a US National Cancer Institute program in 1962. Monroe E. Wall and Mansukh C. Wani isolated it from the bark of a Pacific yew tree. Upon doing more research, they discovered that endophytic fungi in the bark of the tree synthesize paclitaxel. In 1977, scientists were able to confirm antitumor activity in mouse melanoma. During this year, Dr. Susan Horwitz discovered that paclitaxel was able to bind to a cell’s microtubule assembly and slow or cease cell division and growth. Ever since 1992, paclitaxel has been used for the treatment of various cancers. <ref>“Horwitz, Susan. “Taxol® (NSC 125973).” National Cancer Institute, dtp.cancer.gov/timeline/flash/success_stories/s2_taxol.htm.</ref>
+Paclitaxel was first discovered in a US National Cancer Institute program in 1962. Monroe E. Wall and Mansukh C. Wani isolated it from the bark of a Pacific yew tree. Upon doing more research, they discovered that endophytic fungi in the bark of the tree synthesize paclitaxel. In 1977, scientists were able to confirm antitumor activity in mouse melanoma. During this year, Dr. Susan Horwitz discovered that paclitaxel was able to bind to a cell’s microtubule assembly and slow or cease cell division and growth. Ever since 1992, paclitaxel has been used for the treatment of various cancers. <ref>“Horwitz, Susan. “Taxol® (NSC 125973).” National Cancer Institute, dtp.cancer.gov/timeline/flash/success_stories/s2_taxol.htm.</ref>
 ==Structure==