User:Cassandra Marsh/Sandbox 2: Difference between revisions

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===Potassium Binding Site===
===Potassium Binding Site===
There are two potassium ions in HDAC8.  While their exact function is unknown, these ions do increase the catalytic activity and stability of the enzyme overall.  The potassium ion closest to the active site becomes a <scene name='81/812841/Potassium_binding_site/4'>Potassium Binding Site</scene>.  The potassium ion octahedrally coordinates with the side chain oxygen of S199 and D176 and the backbone oxygen of D176, D178, H180 and L200 <ref name="Chen">PMID:25060069</ref>.  Because the second potassium ion is about 20 Å from the catalytic center, this only regulates the enzymatic activity by an allosteric effect <ref name="Chen" />.
There are two potassium ions in HDAC8.  While their exact function is unknown, these ions do increase the catalytic activity and stability of the enzyme overall.  The potassium ion closest to the active site becomes a <scene name='81/812841/Potassium_binding_site/5'>Potassium Binding Site</scene>.  The potassium ion octahedrally coordinates with the side chain oxygen of S199 and D176 and the backbone oxygen of D176, D178, H180 and L200 <ref name="Chen">PMID:25060069</ref>.  Because the second potassium ion is about 20 Å from the catalytic center, this only regulates the enzymatic activity by an allosteric effect <ref name="Chen" />.




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