Gamma secretase: Difference between revisions
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== Gamma Secretase Interaction In Alzheimer's Disease == | == Gamma Secretase Interaction In Alzheimer's Disease == | ||
'''Gamma-secretase''' (GS) is a multi-subunit protease complex which cleaves many transmembrane proteins; it is known as an intramembrane protease. γ-secretase is highly studied in its cleavage of amyloid precursor protein (APP) releasing beta-amyloid (Aβ peptides) which further oligomerize to form neurofibrillary tangles and plaques in Alzheimer’s disease.<ref name= "mckeon">DOI: 10.1016/B978-012351830-9/50024-X</ref> | '''Gamma-secretase''' (GS) is a multi-subunit protease complex which cleaves many transmembrane proteins; it is known as an intramembrane protease. γ-secretase is highly studied in its cleavage of amyloid precursor protein (APP) releasing beta-amyloid (Aβ peptides) which further oligomerize to form neurofibrillary tangles and plaques in Alzheimer’s disease.<ref name= "mckeon">DOI: 10.1016/B978-012351830-9/50024-X</ref> | ||
<StructureSection load=' | <StructureSection load='5A63' size='340' side='right' caption='Gamma Secretase Complex' scene=''> | ||
This is a default text for your page '''Gamma secretase complex'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page '''Gamma secretase complex'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
