User:Steve Klimcak/Sandbox 1: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 20: | Line 20: | ||
==Application== | ==Application== | ||
LSD1 plays a pivital role in many biological processes such as cell growth, epithelial-mesenchymal transition, stem cell biology, malignant transformation of cells, and cell differentiation. Malfunctioning of these activities can lead to life threatening diseases such as acute myeloid leukemia and acute lymphoblastic leukemia. Evidence has shown that these activities have ties to prostate and small cell lung cancer so studies have been done to find a reliable inhibitor for LSD1. Monamine oxidases utilize the FAD co-factor much like LSD1 and inhibitors of monamaine oxidase have proven to be successful in inhibiting the activity of LSD1. Thus inhibition of LSD1 opens new pathways for possible treatments for cancers and disorders. | |||
== Disease == | == Disease == | ||
| Line 33: | Line 33: | ||
<ref name=”Ransey”>PMID:28504306</ref> | <ref name=”Ransey”>PMID:28504306</ref> | ||
<ref name="Khalid">PMID:16275784</ref> | <ref name="Khalid">PMID:16275784</ref> | ||
<ref name="Abdel-Magid">PMID:29152043</ref> | |||
<references/> | <references/> | ||
