6obh: Difference between revisions
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==Structure of HIV-1 CA 1/2-hexamer== | |||
<StructureSection load='6obh' size='340' side='right'caption='[[6obh]], [[Resolution|resolution]] 2.96Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6obh]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OBH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OBH FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6ecn|6ecn]], [[6eco|6eco]], [[6ec2|6ec2]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6obh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6obh OCA], [http://pdbe.org/6obh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6obh RCSB], [http://www.ebi.ac.uk/pdbsum/6obh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6obh ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The HIV-1 capsid is an ordered protein shell that houses the viral genome during early infection. Its expansive surface consists of an ordered and interfacing array of capsid protein hexamers and pentamers that are recognized by numerous cellular proteins. Many of these proteins recognize specific, assembled capsid interfaces not present in unassembled capsid subunits. We used protein-engineering tools to capture diverse capsid assembly intermediates. We built a repertoire of capsid assemblies (ranging from two to 42 capsid protein molecules) that recreate the various surfaces in infectious capsids. These assemblies reveal unique capsid-targeting mechanisms for each of the anti-HIV factors, TRIMCyp, MxB, and TRIM5alpha, linked to inhibition of virus uncoating and nuclear entry, as well as the HIV-1 cofactor FEZ1 that facilitates virus intracellular trafficking. This capsid assembly repertoire enables elucidation of capsid recognition modes by known capsid-interacting factors, identification of new capsid-interacting factors, and potentially, development of capsid-targeting therapeutics. | |||
Modular HIV-1 Capsid Assemblies Reveal Diverse Host-Capsid Recognition Mechanisms.,Summers BJ, Digianantonio KM, Smaga SS, Huang PT, Zhou K, Gerber EE, Wang W, Xiong Y Cell Host Microbe. 2019 Aug 14;26(2):203-216.e6. doi: 10.1016/j.chom.2019.07.007. PMID:31415753<ref>PMID:31415753</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6obh" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Summers, B J]] | |||
[[Category: Xiong, Y]] | |||
[[Category: Capsid]] | |||
[[Category: Disulfide]] | |||
[[Category: Viral protein]] | |||
Revision as of 15:31, 28 August 2019
Structure of HIV-1 CA 1/2-hexamer
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