6r7x: Difference between revisions

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'''Unreleased structure'''


The entry 6r7x is ON HOLD
==CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (2mM Ca2+, closed form)==
 
<StructureSection load='6r7x' size='340' side='right'caption='[[6r7x]], [[Resolution|resolution]] 3.47&Aring;' scene=''>
Authors: Pike, A.C.W., Bushell, S.R., Shintre, C.A., Tessitore, A., Baronina, A., Chu, A., Mukhopadhyay, S., Shrestha, L., Chalk, R., Burgess-Brown, N.A., Love, J., Huiskonen, J.T., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Carpenter, E.P., Structural Genomics Consortium (SGC)
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6r7x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R7X FirstGlance]. <br>
Description: CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (2mM Ca2+, closed form)
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=UMQ:UNDECYL-MALTOSIDE'>UMQ</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r7x OCA], [http://pdbe.org/6r7x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r7x RCSB], [http://www.ebi.ac.uk/pdbsum/6r7x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r7x ProSAT]</span></td></tr>
[[Category: Shintre, C.A]]
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/ANO10_HUMAN ANO10_HUMAN]] Adult-onset autosomal recessive cerebellar ataxia. The disease is caused by mutations affecting the gene represented in this entry.  
== Function ==
[[http://www.uniprot.org/uniprot/ANO10_HUMAN ANO10_HUMAN]] Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.<ref>PMID:20056604</ref> <ref>PMID:22946059</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Baronina, A]]
[[Category: Baronina, A]]
[[Category: Pike, A.C.W]]
[[Category: Bountra, C]]
[[Category: Arrowsmith, C.H]]
[[Category: Burgess-Brown, N A]]
[[Category: Bushell, S R]]
[[Category: Carpenter, E P]]
[[Category: Chalk, R]]
[[Category: Chalk, R]]
[[Category: Chu, A]]
[[Category: Edwards, A M]]
[[Category: Huiskonen, J T]]
[[Category: Love, J]]
[[Category: Mukhopadhyay, S]]
[[Category: Pike, A C.W]]
[[Category: Structural genomic]]
[[Category: Shintre, C A]]
[[Category: Shrestha, L]]
[[Category: Shrestha, L]]
[[Category: Love, J]]
[[Category: Burgess-Brown, N.A]]
[[Category: Huiskonen, J.T]]
[[Category: Chu, A]]
[[Category: Tessitore, A]]
[[Category: Tessitore, A]]
[[Category: Mukhopadhyay, S]]
[[Category: Calcium activation]]
[[Category: Edwards, A.M]]
[[Category: Lipid transport]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Membrane protein]]
[[Category: Bushell, S.R]]
[[Category: Sgc]]
[[Category: Bountra, C]]
[[Category: Transport protein]]
[[Category: Carpenter, E.P]]
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