6r9k: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6r9k is ~~ON HOLD~~

==A quadruplex hybrid structure with lpp loop orientation and 3 syn residues==

== Structural highlights ==

<table><tr><td colspan='2'>[[6r9k]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R9K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R9K FirstGlance]. <br>

</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGM:8-BROMO-2-DEOXYGUANOSINE-5-MONOPHOSPHATE'>BGM</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r9k OCA], [http://pdbe.org/6r9k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r9k RCSB], [http://www.ebi.ac.uk/pdbsum/6r9k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r9k ProSAT]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

The oligomer d(GCGTG3 TCAG3 TG3 TG3 ACGC) with short complementary flanking sequences at the 5'- and 3'-ends was shown to fold into three different DNA G-quadruplex species. In contrast, a corresponding oligomer that lacks base complementarity between the two overhang sequences folds into a single parallel G-quadruplex. The three coexisting quadruplex structures were unambiguously identified and structurally characterized through detailed spectral comparisons with well-defined G-quadruplexes formed upon the deliberate incorporation of syn-favoring 8-bromoguanosine analogues into specific positions of the G-core. Two (3+1) hybrid structures coexist with the parallel fold and feature a novel lateral-propeller-propeller loop architecture that has not yet been confirmed experimentally. Both hybrid quadruplexes adopt the same topology and only differ in their pattern of anti-->syn transitions and tetrad stackings.

~~Authors:~~ Karg, B., Weisz, K.

Duplex-Guided Refolding into Novel G-Quadruplex (3+1) Hybrid Conformations.,Karg B, Mohr S, Weisz K Angew Chem Int Ed Engl. 2019 May 28. doi: 10.1002/anie.201905372. PMID:31134741<ref>PMID:31134741</ref>

~~Description~~: ~~A quadruplex hybrid structure with lpp loop orientation and 3 syn residues~~

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

[[Category: ~~Unreleased~~ Structures]]

</div>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Karg, B]]

[[Category: Weisz, K]]

[[Category: 8-bromoguanosine]]

[[Category: Dna]]

[[Category: G-quadruplex]]

[[Category: Hybrid structure]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6r9k is ON HOLD
+==A quadruplex hybrid structure with lpp loop orientation and 3 syn residues==
+<StructureSection load='6r9k' size='340' side='right'caption='[[6r9k]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6r9k]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R9K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R9K FirstGlance]. <br>
+</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGM:8-BROMO-2-DEOXYGUANOSINE-5-MONOPHOSPHATE'>BGM</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r9k OCA], [http://pdbe.org/6r9k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r9k RCSB], [http://www.ebi.ac.uk/pdbsum/6r9k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r9k ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The oligomer d(GCGTG3 TCAG3 TG3 TG3 ACGC) with short complementary flanking sequences at the 5'- and 3'-ends was shown to fold into three different DNA G-quadruplex species. In contrast, a corresponding oligomer that lacks base complementarity between the two overhang sequences folds into a single parallel G-quadruplex. The three coexisting quadruplex structures were unambiguously identified and structurally characterized through detailed spectral comparisons with well-defined G-quadruplexes formed upon the deliberate incorporation of syn-favoring 8-bromoguanosine analogues into specific positions of the G-core. Two (3+1) hybrid structures coexist with the parallel fold and feature a novel lateral-propeller-propeller loop architecture that has not yet been confirmed experimentally. Both hybrid quadruplexes adopt the same topology and only differ in their pattern of anti--&gt;syn transitions and tetrad stackings.
-Authors: Karg, B., Weisz, K.
+Duplex-Guided Refolding into Novel G-Quadruplex (3+1) Hybrid Conformations.,Karg B, Mohr S, Weisz K Angew Chem Int Ed Engl. 2019 May 28. doi: 10.1002/anie.201905372. PMID:31134741<ref>PMID:31134741</ref>
-Description: A quadruplex hybrid structure with lpp loop orientation and 3 syn residues
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
+<div class="pdbe-citations 6r9k" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Karg, B]]
 [[Category: Weisz, K]]
+[[Category: 8-bromoguanosine]]
+[[Category: Dna]]
+[[Category: G-quadruplex]]
+[[Category: Hybrid structure]]