4o9h: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 3: | Line 3: | ||
<StructureSection load='4o9h' size='340' side='right'caption='[[4o9h]], [[Resolution|resolution]] 2.42Å' scene=''> | <StructureSection load='4o9h' size='340' side='right'caption='[[4o9h]], [[Resolution|resolution]] 2.42Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4o9h]] is a 3 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4o9h]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O9H FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o9h OCA], [https://pdbe.org/4o9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o9h RCSB], [https://www.ebi.ac.uk/pdbsum/4o9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o9h ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN] Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[https://omim.org/entry/604302 604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men. | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. | ||
==See Also== | ==See Also== | ||
*[[Interleukin|Interleukin]] | *[[Interleukin 3D structures|Interleukin 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Lama glama]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Blanchetot | [[Category: Blanchetot C]] | ||
[[Category: Cambillau | [[Category: Cambillau C]] | ||
[[Category: Desmyter | [[Category: De haard HJW]] | ||
[[Category: Dreier | [[Category: Desmyter A]] | ||
[[Category: Hemrika | [[Category: Dreier T]] | ||
[[Category: Hultberg | [[Category: Hemrika W]] | ||
[[Category: Klarenbeek | [[Category: Hultberg A]] | ||
[[Category: Kretz-rommel | [[Category: Klarenbeek A]] | ||
[[Category: Ongenae | [[Category: Kretz-rommel A]] | ||
[[Category: Roovers | [[Category: Ongenae N]] | ||
[[Category: Sadi | [[Category: Roovers RC]] | ||
[[Category: Schragel | [[Category: Sadi AS]] | ||
[[Category: Spinelli | [[Category: Schragel G]] | ||
[[Category: Wijdenes | [[Category: Spinelli S]] | ||
[[Category: Wijdenes J]] | |||
Revision as of 07:12, 25 January 2023
Structure of Interleukin-6 in complex with a Camelid Fab fragment
| ||||||||||||
