3bv2: Difference between revisions

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[[Image:3bv2.jpg|left|200px]]
{{Seed}}
[[Image:3bv2.png|left|200px]]


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{{STRUCTURE_3bv2|  PDB=3bv2  |  SCENE=  }}  
{{STRUCTURE_3bv2|  PDB=3bv2  |  SCENE=  }}  


'''Morpholino pyrrolotriazine P38 Alpha map kinase inhibitor compound 30'''
===Morpholino pyrrolotriazine P38 Alpha map kinase inhibitor compound 30===




==Overview==
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A novel series of compounds based on the pyrrolo[2,1-f][1,2,4]triazine ring system have been identified as potent p38alpha MAP kinase inhibitors. The synthesis, structure-activity relationships (SAR), and in vivo activity of selected analogs from this class of inhibitors are reported. Additional studies based on X-ray co-crystallography have revealed that one of the potent inhibitors from this series binds to the DFG-out conformation of the p38alpha enzyme.
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==About this Structure==
==About this Structure==
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[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:02:54 2008''
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