SCP2-thiolase: Difference between revisions
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== Function and Disease== | == Function and Disease== | ||
The SCP2 thiolase functions in the bile acid synthesis pathway <ref>pmid 9325339</ref>. SCP2-thiolase is synthesised as a larger protein, having the thiolase part and at the C-terminal end there is an extra domainn, the SCP2-domain. This domain has the sequence SKL at its C-terminus, which functions as the peroxisomal targetting sequence. In the peroxisome the SCP2-domain is proteolytically cleaved off, and the SCP2-thiolase chain is found to be present in the peroxisome, as described by Wanders and coworkers, who also described the deficiency symptoms in case the SCP2-thiolase is not properly expressed. <ref>pmid 16685654</ref> | The SCP2 thiolase functions in the bile acid synthesis pathway <ref>pmid 9325339</ref>. SCP2-thiolase is synthesised as a larger protein, having the thiolase part and at the C-terminal end there is an extra domainn, the SCP2-domain. This domain has the sequence SKL at its C-terminus, which functions as the peroxisomal targetting sequence. In the peroxisome the SCP2-domain is proteolytically cleaved off, and the SCP2-thiolase chain is found to be present in the peroxisome, as described by Wanders and coworkers, who also described the deficiency symptoms in case the SCP2-thiolase is not properly expressed. <ref>pmid 16685654</ref> | ||
== Structural highlights == | == Structural highlights == | ||
