6raa: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 6raa is ~~ON HOLD~~

==CLK1 Kinase domain with bound imidazopyridin inhibitor TP003==

~~Authors~~: ~~Schroeder~~, M., ~~Arrowsmith~~, C., ~~Knapp~~, S., ~~Bountra~~, C., ~~Edwards~~, A., ~~Structural Genomics Consortium~~ (~~SGC~~)

== Structural highlights ==

<table><tr><td colspan='2'>[[6raa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RAA OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RAA FirstGlance].

~~Description~~: ~~CLK1 Kinase domain with bound imidazopyridin inhibitor TP003~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JWN:4-[2-methyl-1-(4-methylpiperazin-1-yl)-1-oxidanylidene-propan-2-yl]-~{N}-(6-pyridin-4-ylimidazo[1,2-a]pyridin-2-yl)benzamide'>JWN</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6raa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6raa OCA], [http://pdbe.org/6raa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6raa RCSB], [http://www.ebi.ac.uk/pdbsum/6raa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6raa ProSAT]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/CLK1_HUMAN CLK1_HUMAN]] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.<ref>PMID:10480872</ref> <ref>PMID:19168442</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Dual-specificity kinase]]

[[Category: Large Structures]]

[[Category: Arrowsmith, C]]

[[Category: Bountra, C]]

[[Category: Edwards, A]]

[[Category: Knapp, S]]

[[Category: Structural genomic]]

[[Category: Schroeder, M]]

[[Category: ~~Knapp, S~~]]

[[Category: Inhibitor]]

[[Category: ~~Structural Genomics Consortium (Sgc)~~]]

[[Category: Kinase]]

[[Category: ~~Edwards, A~~]]

[[Category: Sgc]]

[[Category: ~~Bountra, C~~]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 6raa is ON HOLD
+==CLK1 Kinase domain with bound imidazopyridin inhibitor TP003==
+<StructureSection load='6raa' size='340' side='right'caption='[[6raa]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-Authors: Schroeder, M., Arrowsmith, C., Knapp, S., Bountra, C., Edwards, A., Structural Genomics Consortium (SGC)
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6raa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RAA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RAA FirstGlance]. <br>
-Description: CLK1 Kinase domain with bound imidazopyridin inhibitor TP003
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JWN:4-[2-methyl-1-(4-methylpiperazin-1-yl)-1-oxidanylidene-propan-2-yl]-~{N}-(6-pyridin-4-ylimidazo[1,2-a]pyridin-2-yl)benzamide'>JWN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6raa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6raa OCA], [http://pdbe.org/6raa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6raa RCSB], [http://www.ebi.ac.uk/pdbsum/6raa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6raa ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/CLK1_HUMAN CLK1_HUMAN]] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA.<ref>PMID:10480872</ref> <ref>PMID:19168442</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Dual-specificity kinase]]
+[[Category: Large Structures]]
 [[Category: Arrowsmith, C]]
+[[Category: Bountra, C]]
+[[Category: Edwards, A]]
+[[Category: Knapp, S]]
+[[Category: Structural genomic]]
 [[Category: Schroeder, M]]
-[[Category: Knapp, S]]
+[[Category: Inhibitor]]
-[[Category: Structural Genomics Consortium (Sgc)]]
+[[Category: Kinase]]
-[[Category: Edwards, A]]
+[[Category: Sgc]]
-[[Category: Bountra, C]]
+[[Category: Transferase]]