6rct: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "6rct" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal structure of CLK3 in complex with TP003== | |||
<StructureSection load='6rct' size='340' side='right'caption='[[6rct]], [[Resolution|resolution]] 2.32Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6rct]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RCT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RCT FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=JWN:4-[2-methyl-1-(4-methylpiperazin-1-yl)-1-oxidanylidene-propan-2-yl]-~{N}-(6-pyridin-4-ylimidazo[1,2-a]pyridin-2-yl)benzamide'>JWN</scene></td></tr> | |||
[[Category: | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rct OCA], [http://pdbe.org/6rct PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rct RCSB], [http://www.ebi.ac.uk/pdbsum/6rct PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rct ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CLK3_HUMAN CLK3_HUMAN]] Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.<ref>PMID:9637771</ref> <ref>PMID:19168442</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Dual-specificity kinase]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith, C H]] | |||
[[Category: Bountra, C]] | |||
[[Category: Chaikuad, A]] | [[Category: Chaikuad, A]] | ||
[[Category: | [[Category: Edwards, A M]] | ||
[[Category: Knapp, S]] | [[Category: Knapp, S]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: | [[Category: Clk3]] | ||
[[Category: | [[Category: Kinase inhibitor]] | ||
[[Category: Probe]] | |||
[[Category: Sgc]] | |||
[[Category: Splicing kinase]] | |||
[[Category: Transferase]] | |||
Revision as of 08:58, 1 May 2019
Crystal structure of CLK3 in complex with TP003
| ||||||||||||
