4pr6: Difference between revisions

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<StructureSection load='4pr6' size='340' side='right'caption='[[4pr6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4pr6' size='340' side='right'caption='[[4pr6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4pr6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1cx0 1cx0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PR6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PR6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4pr6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1cx0 1cx0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PR6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PR6 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pr6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pr6 OCA], [https://pdbe.org/4pr6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pr6 RCSB], [https://www.ebi.ac.uk/pdbsum/4pr6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pr6 ProSAT]</span></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4prf|4prf]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SNRPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pr6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pr6 OCA], [http://pdbe.org/4pr6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pr6 RCSB], [http://www.ebi.ac.uk/pdbsum/4pr6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pr6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN]] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>
[https://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Ribozyme|Ribozyme]]
*[[Ribozyme 3D structures|Ribozyme 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Doudna, J A]]
[[Category: Doudna JA]]
[[Category: Jain, S]]
[[Category: Jain S]]
[[Category: Kapral, G J]]
[[Category: Kapral GJ]]
[[Category: Noeske, J]]
[[Category: Noeske J]]
[[Category: Richardson, D C]]
[[Category: Richardson DC]]
[[Category: Richardson, J S]]
[[Category: Richardson JS]]
[[Category: Base sequence]]
[[Category: Binding site]]
[[Category: Catalysis]]
[[Category: Catalytic]]
[[Category: Cloning]]
[[Category: Computer graphic]]
[[Category: Escherichia coli]]
[[Category: Hepatitis delta virus]]
[[Category: Model]]
[[Category: Molecular]]
[[Category: Molecular sequence data]]
[[Category: Nucleic acid conformation]]
[[Category: Ribonucleoprotein]]
[[Category: Rna]]
[[Category: Rna binding protein-rna complex]]
[[Category: Rna binding protein/rna]]
[[Category: Rna-binding protein]]
[[Category: U1 small nuclear]]
[[Category: Viral]]
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